Hemodynamic effects of atrial natriuretic peptide in ischemia-reperfusioninjury that occurs after exercise

Vardar, Selma Arzu; Palabıyık, Orkide; Topuz, Ruhan Deniz; Gürel, Elif Ezgi; Çalişkan, Semra; Özen, Serap Topçu; Süt, Necdet; Karadağ, Çetin Hakan

doi:10.3906/sag-1307-42

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…Although isatin is reported as a natriuretic receptor blocker, we did not observe any alteration on the improved left ventricle function of ANP. These findings were compatible to our previous results that different doses of isatin did not affect cardiac contractility and relaxation functions of ANP when administered before ischemia in isolated rat heart (16) . However, some experimental studies have reported that isatin could limit the protective effect of ANP and brain natriuretic peptide following ischemia and reperfusion condition in the heart (14,17) .…”

Section: Discussionsupporting

confidence: 93%

Effect of Isatin on Ischemia and Reperfusion Injury: an Experimental Study in the Isolated Rat Heart

Guksu¹,

Palabıyık²,

Karaca³

et al. 2019

Kosuyolu Heart Journal

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Introduction: Isatin is an endogen indole that is found in body fluids and reported as a neuroprotective, anticonvulsant, and sedative agent. The aim of the present study was to investigate the effects of isatin on left ventricle functions before and after low-flow ischemia in the isolated rat heart. Patients and Methods: Male Wistar rats were divided into four groups. Isatin (I, 50 mg/kg intraperitoneally) was administered in the I and I-atrial natriuretic peptide (ANP) groups 20 min before the hearts were placed on the Langendorff apparatus. Serum physiologic was administered to the control (C) and ANP groups. Low-flow ischemia was applied in all groups. ANP (0.1 μM/L) was added to perfusion solution in the ANP and I + ANP groups 15 min before ischemia. Left ventricular developed pressure (LVDP) and maximum and minimum pressure changes were recorded before and after ischemia. Cyclic guanosine monophosphate (cGMP) levels were measured in the perfusate in all groups. Results: LVDP and minimum pressure change values of the I group were found to be similar to the C group at 60 min of reperfusion. The level of cGMP in the I group was similar to the C group but lower than the ANP and I + ANP groups before and after ischemia. Conclusion: The administration of isatin prior to cardiac ischemia does not significantly alter cardiac function during the reperfusion period in rat heart. The results of the present study showed that isatin may not appear to have a disturbing effect on cardiac functions after low-flow ischemia.

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Section: Discussionsupporting

confidence: 93%

Effect of Isatin on Ischemia and Reperfusion Injury: an Experimental Study in the Isolated Rat Heart

Guksu¹,

Palabıyık²,

Karaca³

et al. 2019

Kosuyolu Heart Journal

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“…Left ventricular end-diastolic pressure (LVEDP) was set at approximately 5-10 mmHg. After baseline recording for 15 minutes, LV developed pressure (LVDP), heart rate (HR), dp/dtmax, dp/dtmin, and LVEDP were continuously recorded for 40 minutes (BIOPAC MP36 System, Inc., USA) [40].…”

Section: Research Articlementioning

confidence: 99%

High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin

MEMI¹,

Öztürk²,

Palabıyık³

2023

jrp

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The obese population has been rapidly increasing because of high-fat consumption and a sedentary lifestyle. Large amounts of dietary fat intake increase the risk of cardiovascular disease. We aimed to investigate the effects of exercise and obestatin on a high-fat diet (HFD) induced cardiac hemodynamic changes. Seventy-nine Sprague-Dawley rats (200 to 250 g) were fed either control diet or HFD for 8 weeks. In the 5th week, each diet group was subgrouped as follows; control, exercise, obestatin (25μg/kg, i.p), exercise+obestatin (25μg/kg, i.p). After the end of 4 weeks of exercise (swimming exercise, 5 days a week/ 20 min day) and obestatin administration period, all animals were sacrificed. Hearts were removed for hemodynamic measurements with the Langendorff apparatus. Blood samples were collected for biochemical measurements. Data were analyzed by Graphpad Prism 6.0. and p<0.05 was accepted as statistically significant. Cardiac contractility and hemodynamic parameters in the HFD model have been evaluated. And the effects of chronic obestatin treatment and exercise were studied together. Obestatin ameliorated derangements in LVDP, heart rate, and blood lipid levels induced by an HFD. Also, obestatin prevents decreasing BNP levels with highfat consumption. Obestatin treatment potentiated the beneficial effects of exercise evidenced by LVDP, heart rate, blood lipids, BNP, and AT2R1 measurements. We believe that obestatin has the potential for the maintenance of cardiac function in HFD.

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Hemodynamic effects of atrial natriuretic peptide in ischemia-reperfusioninjury that occurs after exercise

Cited by 2 publications

References 23 publications

Effect of Isatin on Ischemia and Reperfusion Injury: an Experimental Study in the Isolated Rat Heart

Effect of Isatin on Ischemia and Reperfusion Injury: an Experimental Study in the Isolated Rat Heart

High-fat diet induced cardiac hemodynamic changes: effects of exercise and obestatin

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