Hemodynamic Effects of Calcium Antagonists at Rest and During Exercise in Essential Hypertension: A Comparison Between Verapamil, Diltiazem, Tiapamil, Nifedipine and Nisoldipine

Lund‐Johansen, Per; Omvik, Per

doi:10.1007/978-4-431-68090-1_28

Cited by 4 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent with reports from pre vious studies using other calcium antagonists [18][19][20]. Reductions in blood pressure with amlodipine in the dose range 5-10 mg were comparable to those seen with other dihydro pyridine calcium antagonists [21] and consis tent with the findings of Frick et al [22].…”

Section: Discussionsupporting

confidence: 82%

Long-Term Haemodynamic Effects of Amlodipine at Rest and during Exercise in Essential Hypertension

Lund‐Johansen

Omvik²,

White³

et al. 1992

Cardiology

Self Cite

View full text Add to dashboard Cite

Haemodynamic responses at rest and during exercise were studied in 18 patients with essential hypertension following long-term treatment with amlodipine. Patients underwent a 2-week placebo run-in period followed by a mean duration of 11 months’ treatment with amlodipine 5-10 mg (mean dose 9 mg) once daily. Blood pressure was measured intra-arterially, cardiac output by dye dilution and heart rate by electrocardiogram. Amlodipine produced a mean reduction in systolic and diastolic arterial pressure of 27 and 16 mm Hg, respectively, at rest and after exercise. At rest sitting, mean systolic and diastolic arterial pressures were reduced by 16 and 14% (p < 0.01), respectively, from initial mean values of 182.4/111.2 mm Hg. This reduction in blood pressure was associated with a marked reduction in the total peripheral resistance index of 19% (p < 0.001). Similar responses were observed at rest supine and during exercise. No significant changes were seen in heart rate. Stroke index showed a small increase at rest and during exercise together with a trend towards an increase in cardiac index after treatment with amlodipine. Ambulatory blood pressure monitoring was carried out in 10 patients after the placebo run-in and at the end of the study. Amlodipine showed effective blood pressure control throughout the 24 h after one daily dose. The incidence of side effects was low (ankle oedema in 2 patients).

show abstract

Section: Discussionsupporting

confidence: 82%

Long-Term Haemodynamic Effects of Amlodipine at Rest and during Exercise in Essential Hypertension

Lund‐Johansen

Omvik²,

White³

et al. 1992

Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…During rest, however, most of (22). The a-blockers, ACE-inhibitors, and calcium-antagonists all reduce the increased TPRI acutely as well as chronically and leave cardiac output undisturbed at rest and during exercise (23,24); the /3-blockers behave differently. Although /9-blockers with strong intrinsic sympathomimetic activity have little effect on cardiac output during rest, all R-blockers reduce exercise cardiac output and exercise heart rate (25,26).…”

Section: Hemodynamic Testingmentioning

confidence: 99%