Hemodynamic effects of epinephrine in rats: evaluation by impedance cardiography

Turkseven, Cagatay Han; Pekoğlu, Esra; Büyükakıllı, Belgin

doi:10.4149/bll_2017_118

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The use of impedance cardiography for hemodynamic measurements may represent another study limitation; this method was shown to potentially over-or underestimate the results during NIV compared to the thermo-dilution method (14). Nevertheless, impedance cardiography is an established non-invasive method to assess hemodynamic functions in both experimental (15) and clinical (16) studies, which is reliable when assessing trends (17).…”

Section: Discussionmentioning

confidence: 99%

Acute hemodynamic effects of non-invasive ventilation in patients with obesity hypoventilation syndrome

Pobeha¹,

Paraničová²,

Trojová³

et al. 2021

BLL

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OBJECTIVE: To evaluate the acute effects of volume-targeted non-invasive ventilation (NIV) on hemodynamic parameters assessed by impedance cardiography in patients with obesity hypoventilation syndrome (OHS). BACKGROUND: Despite the well-described benefi cial effects of NIV using volume-targeted pressure support ventilation modes on respiration in OHS patients, questions were raised about the impact of this treatment on the cardiovascular system. METHODS: In 15 patients (10 men; mean age, 55.8±9.3 years) impedance cardiography recordings were taken at baseline, after 120 minutes while on NIV and 20 minutes after NIV termination. A repeated-measures analysis of variance was used for comparisons. RESULTS: Compared to baseline, a reduction in heart rate (from 80±11 to 73±10 beats per min, p<0.05) was observed on NIV whereas the stroke volume and cardiac index remained stable throughout all three assessed intervals (p=0.347, p=0.344; respectively). The pre-ejection period increased on NIV (from 113±16 to 127±20 ms, p<0.05), and the left ventricular ejection time increased after NIV termination compared to baseline (from 259±25 to 269±25 ms, p<0.05). CONCLUSION: Volume-targeted NIV may acutely improve systolic time intervals without any negative impact on the left ventricular function in OHS patients (Tab. 2, Ref. 17).

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Section: Discussionmentioning

confidence: 99%

Acute hemodynamic effects of non-invasive ventilation in patients with obesity hypoventilation syndrome

Pobeha¹,

Paraničová²,

Trojová³

et al. 2021

BLL

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“…The second key parameter triggered by EE was post-resuscitation hypertension. Blood pressure is directly associated with vasoconstriction (α-agonist effect) and cardiac output (β-agonist effect) (14, 46, 47). Therefore, we suspected that early administration might maximize the dual effects (α and β agonist effects) of epinephrine and then ROSC would be easier to establish.…”

Section: Discussionmentioning

confidence: 99%

“…On the one hand, greater systemic vascular resistance might be detrimental to an end organ by limiting perfusion/cardiac output to that organ. On the other hand, it has been shown that EE provides benefit by increasing coronary artery perfusion pressure, and this might be associated with better outcomes (46, 48). Nevertheless, post-resuscitation oxygenation, rhythm, level of consciousness, body temperature, and urine output were not significantly associated with EE.…”

Section: Discussionmentioning

confidence: 99%

Early Epinephrine Improves the Stabilization of Initial Post-resuscitation Hemodynamics in Children With Non-shockable Out-of-Hospital Cardiac Arrest

Lin

Huang

et al. 2019

Front. Pediatr.

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Background: In children with non-shockable out-of-hospital cardiac arrest, early epinephrine (EE) might help to establish the return of spontaneous circulation (ROSC) and be associated with survival. In the present study, we aimed to analyze the effects of EE on outcomes and post-resuscitation hemodynamics in children with non-shockable OHCA. Methods: This was a retrospective analysis of data from 216 children (<19 years) who had suffered non-traumatic and non-shockable OHCA and received epinephrine for resuscitation (Jan 1, 2006–Dec 31, 2014). Demographics, pre-/in-hospital information, and the time to the first dose of epinephrine were recorded. Early post-resuscitation hemodynamics (the first hour after sustained ROSC), survival and good neurological outcomes (Pediatric Cerebral Performance Category Scales 1 or 2) were analyzed by the time to epinephrine—classified as early (EE): <15 min, intermediate (IE): 15–30 min, or late (LE): >30 min. Results: Twenty-eight (13.0%) children survived to discharge, but only 17 (7.9%) had good neurological outcomes. In all, 41 (18.9%) children received EE; in comparison to IE and LE, this was significantly associated with tachycardia (73.9%) in the post-resuscitation period ( p < 0.05). Tachycardia (OR: 7.41, 95% CI: 1.96–29.31) and hypertension (OR: 6.03, 95% CI: 1.85–13.77) were significantly associated with EE after adjusting for confounding factors. EE was also significantly associated with better overall outcomes than ME and LE (any ROSC, sustained ROSC, survival to the intensive care unit, admission, survival to discharge and good neurological outcomes, all p < 0.05). Conclusions: EE helped to establish ROSC but was also associated with more tachycardia and hypertension in the early post-resuscitation period. In children with non-traumatic and non-shockable OHCA, EE was associated with a higher survival rate and better neurological outcomes than were ME and LE.

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Eco-friendly in-situ gap generation of no-spacer triboelectric nanogenerator for monitoring cardiovascular activities

et al. 2021

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Hemodynamic effects of epinephrine in rats: evaluation by impedance cardiography

Abstract: Tachycardia was detected in the epinephrine group. There was an inverse correlation between LVET and dZmax/dt and IC. This is based on the fact that epinephrine increases inotropic effect (Tab. 2, Fig. 4, Ref. 30).

Cited by 4 publications

References 15 publications

Acute hemodynamic effects of non-invasive ventilation in patients with obesity hypoventilation syndrome

Acute hemodynamic effects of non-invasive ventilation in patients with obesity hypoventilation syndrome

Early Epinephrine Improves the Stabilization of Initial Post-resuscitation Hemodynamics in Children With Non-shockable Out-of-Hospital Cardiac Arrest

Eco-friendly in-situ gap generation of no-spacer triboelectric nanogenerator for monitoring cardiovascular activities

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