1997
DOI: 10.1016/s0002-8703(97)70149-2
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Hemodynamic effects of fructose 1,6-diphosphate in patients with normal and impaired left ventricular function

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Cited by 19 publications
(15 citation statements)
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“…Following angioplasty, FDP would improve ventricular function following ischemia as has been shown by many studies (14,16,20,23,26,28), resulting in prevention of ischemic injury to the myocardium. Further, FDP has been shown to prevent arrhythmias during reperfusion (13,32).…”
Section: Discussionmentioning
confidence: 81%
“…Following angioplasty, FDP would improve ventricular function following ischemia as has been shown by many studies (14,16,20,23,26,28), resulting in prevention of ischemic injury to the myocardium. Further, FDP has been shown to prevent arrhythmias during reperfusion (13,32).…”
Section: Discussionmentioning
confidence: 81%
“…This process yields only two molecules of ATP per glucose as opposed to the 36 molecules of ATP generated during oxidative phosphorylation. Moreover, associated with this reliance on glycolysis is lactic acid accumulation, which inhibits the pH sensitive phosphofructokinase (PFK) enzyme, 1 and subsequently halts the production of fructose 1,6-diphosphate (FDP) along with the remaining substrates of glycolysis. As a result, the glucose present in Initial concerns over the utilization of FDP as an energetic enhancer hinged upon its permeability to the cell membrane.…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the peak at 3.53 min was indeed FDP. The resolutions of chromatographic peaks between FDP and D-fructose-6-phosphate, D-glucose-6-phosphate or sodium dihydrogen phosphate were 7.487 (usp), 6.373 (usp) and 4.863 (usp), respectively, all being greater than 1.5, indicating that the target FDP was completely separated from the three above compounds. With the 50 mM KOH eluent, the samples of the FDP fermentation broth (diluted 2000-fold) were analyzed and FDP was also completely separated from other compounds (Figure 4).…”
mentioning
confidence: 94%
“…Subsequently, great efforts were made to study FDP physiological functions. It is known that FDP can enhance cell metabolism and cardiac myocyte nutrients, build up the resistance to convulsions, improve anoxic organ performance [3][4][5][6][7][8][9]. Now it is primarily used as a rescue drug for shock patients, in addition to, or used for angina pectoris, heart failure, myocardial infarction secondary treatment, in the cardiovascular acute and chronic disease treatment and prevention with an important role.…”
Section: Introductionmentioning
confidence: 99%