Hemodynamic Effects of Group A Streptococcus Mucopeptide

Masek, K; Paegelow, I.; Rašková, H; Pávek, K; Rotta, J

doi:10.3181/00379727-144-37733

Cited by 6 publications

(1 citation statement)

References 1 publication

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“…The exact mechanism of action of the majority of them has not been known so far. We have been investigating, as a number of others, the effect of compounds from a group of glycopeptides which have been first described and synthesized by Lederer' s group [1][2][3][4], Some of our previous re sults suggested an interaction of this class of compounds with autonomic nervous system [5,6]. This possibility was extended by the reports on smooth muscle stimulation by mu ramyl dipeptide (MDP) [7,8).…”

Section: Introductionmentioning

confidence: 87%

Smooth Muscle Stimulation by an Immunomodulatory Compound Muramyl Dipeptide: Does It Involve Serotoninergic System?

Kadlec¹,

Mašek²,

Gulda³

et al. 1984

Pharmacology

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Contractions evoked by muramyl dipeptide (MDP), a synthetic compound possessing immunostimulatory properties, were studied in several isolated nerve-smooth muscle preparations. The contractions by micromolar concentrations of MDP were evoked either by direct interaction with smooth muscle (rat stomach strip) or at least partly indirectly via neurogenic stimulation (guinea pig ileum); the effect was stereospecific since the MDP-D was not active. The insensitivity of the preparations to serotonin (5-HT), either inherent (vas deferens) or after 5-HT antagonists or after desensitization to 5-HT, prevented or markedly reduced the contractile activity by MDP. On the other hand, a nanomolar concentration of MDP enhanced the sensitivity of the rat stomach strip to 5-HT.

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Section: Introductionmentioning

confidence: 87%

Smooth Muscle Stimulation by an Immunomodulatory Compound Muramyl Dipeptide: Does It Involve Serotoninergic System?

Kadlec¹,

Mašek²,

Gulda³

et al. 1984

Pharmacology

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Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan

Lavický

Černý²,

Čeleda³

et al. 1986

European Journal of Drug Metabolism and Pharmacokinetics

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Trimethoprim (TMP) 10 mg.kg-1 was given orally to calves and rabbits. Two to three weeks later the animals were pretreated by i.v. Peptidoglycan (Pt) 20 micrograms.kg-1. One hour later TMP was administered as above. To other animals under otherwise identical conditions TMP was injected intravenously. The pretreatment with Peptidoglycan induced in both species a significant increase of TMP serum levels positively correlated with temperature elevation. Peptidoglycan pretreatment increased the bioavailability of TMP.

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The effects of peptidoglycan, a pyrogenic constituent of gram-positive microorganisms, on the pharmacokinetics of rifampicin

Lavický¹,

Urbanová²,

Rašková³

et al. 1988

Toxicon

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Hemodynamic Effects of Group A Streptococcus Mucopeptide

Cited by 6 publications

References 1 publication

Smooth Muscle Stimulation by an Immunomodulatory Compound Muramyl Dipeptide: Does It Involve Serotoninergic System?

Smooth Muscle Stimulation by an Immunomodulatory Compound Muramyl Dipeptide: Does It Involve Serotoninergic System?

Changes of pharmacokinetics of Trimethoprim after pretreatment with streptococcal Peptidoglycan

The effects of peptidoglycan, a pyrogenic constituent of gram-positive microorganisms, on the pharmacokinetics of rifampicin

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