“…In a population undergoing a variety of surgical interventions including coronary revascularization, valve repair and replacement, mechanical assist device implantation, and cardiac transplantation, inhaled NO, given at a dose of 20 ppm for a mean of 36 hours, improved pulmonary and systemic arterial pressures and cardiac index (226). Other studies have shown similar benefits of NO in more homogenous populations with PH following valve surgery (227), ventricular assist device implantation (224), and cardiac transplantation (228). On balance, inhaled NO is an effective short-term strategy for the management of PH following cardiac surgery.…”