Hemodynamic effects of magnesium sulfate on the normal human heart

Vigorito, Carlo; Giordano, Arturo; Ferraro, Paolo; Acanfora, Domenico; Caprio, L. De; Naddeo, Corrado; Rengo, Franco

doi:10.1016/0002-9149(91)90478-4

Cited by 75 publications

(30 citation statements)

References 13 publications

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“…It is also thought that the magnesium blocks calcium receptors by inhibiting N-methyl-Daspartate receptors in the brain. [16] Magnesium also produces a peripheral (predominantly arteriolar) vasodilatation [17] thus reducing the blood pressure. It also acts competitively in blocking the entry of calcium into synaptic endings thus altering neuromuscular transmission.…”

Section: Mechanism Of Actionmentioning

confidence: 99%

The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia

Tukur

2009

Ann Afr Med

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Background: Pre-eclampsia and eclampsia are important causes of maternal and perinatal morbidity and mortality in the developing countries. There is need to provide the most effective management to pre-eclamptic and eclamptic patients. There is now evidence that magnesium sulphate is the most effective anticonvulsant. Method: In this article, a literature review was made on the contribution of pre-eclampsia and eclampsia to maternal mortality and how it can be curtailed by the use of magnesium sulphate. Results: The drug is administered by the Pritchard or Zuspan regimen, although modifi cations in the two protocols have been reported. Conclusion: A Nigerian national protocol has been developed on its use. There is need for further training of health workers on how to use this important drug.

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Section: Mechanism Of Actionmentioning

confidence: 99%

The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia

Tukur

2009

Ann Afr Med

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“…Oral magnesium supplementation has also been reported to British Journal of Phamacology (1995Phamacology ( ) 115, 1455Phamacology ( -1462 -ME funct-on iSH lower blood pressure in patients with essential hypertension (Motoyama et al, 1989), and intravenous Mg2" infusion to dilate coronary arteries in man (Vigorito et al, 1991). Since the long-term effects of magnesium supplementation on blood pressure during increased calcium intake are unknown, the present investigation was undertaken; we also examined the associated effects on arterial function and electrolyte balance in SHR and their normotensive control strain Wistar-Kyoto (WKY) rats.…”

Section: Introductionmentioning

confidence: 99%

Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity

Mäkynen

Kähönen

Arvola

et al. 1995

British J Pharmacology

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1 High calcium diet attenuates the development of hypertension but an associated undesirable effect is that Mg2e loss to the urine is enhanced. Therefore, we studied the effects of high calcium diet alone and in combination with increased magnesium intake on blood pressure and arterial function. 2 Forty-eight young spontaneously hypertensive rats (SHR) were allocated into four groups, the dietary contents of Ca2" and Mg2+ being: 1.1%, 0.2% (SHR); 2.5%, 0.2% (Ca-SHR); 2.5%, 0.8% (CaMg-SHR); and 1.1%, 0.8% (Mg-SHR), respectively. Development of hypertension was followed for 13 weeks, whereafter electrolyte balance, lymphocyte intracellular free calcium ([Ca2+]

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“…4 This is well established and there have been number of ways to control or reduce the stress response evoked by such stimuli. 21 Magnesium is already studied and has been proved to attenuate the sympathetic outburst during stress. We planned this study, to compare intravenous magnesium sulphate (30 mg/kg) versus sublingual nitroglycerine spray (2 puffs of 0.4 mg/spray) in attenuating the cardiovascular effects of the stress response during Laryngoscopy and intubation.…”

Section: Resultsmentioning

confidence: 99%

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

Kotwani

Hiwarkar³

2018

Int J Clin Trials

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Background: Laryngoscopy and tracheal Intubation are invariably associated with certain stress responses due to the sympatho-adrenal stimulation. These cardiovascular and neurohumoral alterations may directly affect the physiology and increase the risk. So far, various drugs have been tried but none has been considered ideal for blunting this presser response. We therefore, planned this comparative study to evaluate and compare the efficacy of intravenous magnesium sulphate (30 mg/kg) versus sublingual nitroglycerine spray (0.4 mg/spray) in attenuating the presser response to Laryngoscopy and Tracheal Intubation.Methods: Fifty patients, aged 15–50 years, scheduled for elective surgery under general anaesthesia, were randomly assigned to one of the two groups of 25 each, Group A (magnesium group) and Group B (nitroglycerine group). Study drug was given 90-120 seconds before tracheal intubation. Heart rate, Systolic blood pressure and Rate pressure product were recorded at different intervals after administering the study drug till 3 minutes after intubation.Results: Mean heart rate was significantly higher from the baseline at all times after administering the study drug in both the groups. Increase in systolic blood pressure as a presser response was limited to 7.25% in Group A and 5.83% in Group B from the baseline after tracheal intubation. There was relative hypotension after administration of the study drug in both the groups.Conclusions: Intravenous magnesium or sublingual nitroglycerine pre-treatment is found to be effective in attenuating the presser response to laryngoscopy and intubation. These drugs may lead to rise in HR but it is transient and dose dependent. However, both the drugs can significantly control the hypertensive response after laryngoscopy and intubation.

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Hemodynamic effects of magnesium sulfate on the normal human heart

Cited by 75 publications

References 13 publications

The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia

The use of magnesium sulphate for the treatment of severe pre-eclampsia and eclampsia

Dietary calcium and magnesium supplements in spontaneously hypertensive rats and isolated arterial reactivity

A prospective randomised study comparing intravenous magnesium sulphate and sublingual nitroglycerine spray in attenuating haemodynamic responses to laryngoscopy and intubation

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