Hemodynamic Effects of Nitrendipine on Systolic Ventricular Function, Diastolic Ventricular Function, and Peripheral Circulation in Essential Hypertension

Kuschnir, E; Castro, ro Víctor Hugo Roa; Boccadoro, Mario; Sgammini, H; Guzman, Luiz; Sgarlatta, H; Castro, Maria Cristina Nobre e

doi:10.1097/00005344-198806124-00008

Cited by 7 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study demonstrated that nitrendipine was effective in reducing blood pressure in mild to moderate hypertensive patients, as reported by other authors [1][2][3][4][5][6][7][8], and its antihypertensive efficacy was comparable to HCT. In our study nitrendipine (20 mg daily) normalized blood pressure (DBP -< 90 mmHg) in 77% of treated hypertensive patients without significant side effects.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Scaglione

Indovina

Parrinello

et al. 1992

Cardiovasc Drug Ther

View full text Add to dashboard Cite

In this study antihypertensive efficacy, safety, and the effects of short-term nitrendipine administration on central and renal hemodynamics were evaluated in mild to moderate hypertensives. Our final goal was to ascertain whether the reduction in blood pressure induced by nitrendipine treatment was associated with maintained renal function. After a run-in period with placebo, 26 hypertensives without cardiac or renal disease were randomly assigned to a double-blind 8-week controlled trial with nitrendipine (N) 20 mg once a day (13 pts) or hydrochlorothiazide (HCT) 25 mg once a day (13 pts). Renal hemodynamic measurements included effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) by radionuclide study using I-131 hippuran and Tc-99m, according to the methods described by Schlegel and Gates, respectively. Effective renal blood flow [ERBF = ERPF/(1-Ht)], filtration fraction (FF = GFR/ERPF), and renal vascular resistance (RVR = MBP x 80/ERBF) were also calculated. Other hemodynamic measurements included cardiac index (CI), left ventricular (LV) ejection fraction (EF), and total peripheral resistance (TPR) measured by the first-pass radionuclide angiography technique. At the end of N or HCT administration significant decreases (p less than 0.001) in SBP, DBP, and MBP vs. baseline values were observed in both hypertensive groups. In the N group a significant decrease (p less than 0.01) in TPR and RVR, and significant increases (p less than 0.05) in CI, ERPF, and ERBF were observed. In the HCT group a significant decrease (p less than 0.05) in RVR was found without significant changes in other hemodynamic parameters. No important side effects were observed with either therapy. In conclusion, nitrendipine was effective in reducting blood pressure in mild to moderate hypertensive patients and exerted favorable effects on cardiac and renal function.

show abstract

Section: Discussionsupporting

confidence: 87%

“…Nitrendipine is a selective, long-acting dihydropyridine calcium antagonist with an important systemic vasodilatatory effect [4]. Its effectiveness in lowering blood pressure has been well documented in animals and humans in acute and prolonged studies.…”

mentioning

confidence: 99%

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Scaglione

Indovina

Parrinello

et al. 1992

Cardiovasc Drug Ther

View full text Add to dashboard Cite

show abstract

“…This mechanism can explain the observation of segmental wall motion impairment in left ventricle regions with ischemic viable myocardium in CCC patients and normal coronary arteries (10). This hypothesis is compatible with preliminary studies showing improved LV function in patients with Chagas' disease acutely treated with isosorbide dinitrate (25) and taking dipyridamole for prolonged periods of time (26). In those studies, however, no clear relation was demonstrated between improvement of LV function and relief of myocardial ischemia.…”

Section: Figure 3 Stress and Redistribution Polar Maps Of Initial Ansupporting

confidence: 56%

Changes in Myocardial Perfusion Correlate With Deterioration of Left Ventricular Systolic Function in Chronic Chagas' Cardiomyopathy

Hiss

Lascala

Maciel

et al. 2009

JACC: Cardiovascular Imaging

View full text Add to dashboard Cite

show abstract

“…Third, several studies have shown myocardial perfusion abnormalities in Chagasic patients related to abnormal myocardial blood flow regulation (Hiss et al, 2009;Simoes et al, 2000). Fourth, long-term dipyridamole administration (with vasodilatator and antiplatelet activity) or short-term isosorbide dinitrate administration (a coronary vasodilatator) improved left ventricular function in Chagas heart disease patients (Kuschnir et al, 1983;Marin-Neto et al, 2007). These findings are corroborated by the report of a prothrombotic state in patients with early stages of chronic Chagas disease (Herrera et al, 2005;Herrera et al, 2003).…”

Section: Microvascular Abnormalities and Ischemiamentioning

confidence: 83%

Chagas disease: Present status of pathogenic mechanisms and chemotherapy

et al. 2010

View full text Add to dashboard Cite

There are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment may be rendered more effective by increasing the activity of anti-Chagasic drugs or by modifying the host's immune response. We have previously shown that glutathione synthesis inhibition increases nifurtimox and benznidazole activity. In addition, there is increasing evidence that cyclooxygenase inhibitors present an important effect on T. cruzi infection. Therefore, we found that aspirin reduced the intracellular infection in RAW 264.7 cells and, decreased myocarditis extension and mortality rates in mice. However, the long-term benefit of prostaglandin inhibition for Chagasic patients is still unknown.

show abstract

Hemodynamic Effects of Nitrendipine on Systolic Ventricular Function, Diastolic Ventricular Function, and Peripheral Circulation in Essential Hypertension

Cited by 7 publications

References 0 publications

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Antihypertensive efficacy and effects of nitrendipine on cardiac and renal hemodynamics in mild to moderate hypertensive patients: Randomized controlled trial versus hydrochlorothiazide

Changes in Myocardial Perfusion Correlate With Deterioration of Left Ventricular Systolic Function in Chronic Chagas' Cardiomyopathy

Chagas disease: Present status of pathogenic mechanisms and chemotherapy

Contact Info

Product

Resources

About