Hemodynamic effects of sex and handedness on the Wisconsin Card Sorting Test: the contradiction between neuroimaging and behavioural results

Cinciute, Sigita; Daktariunas, Algis; Rukšėnas, Osvaldas

doi:10.7717/peerj.5890

Cited by 7 publications

(6 citation statements)

References 91 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cognitive performance of five different tasks were not significantly different between the sitting and leaning workstations, which was not consistent with the results of the fNIR data. This indicates that changes of hemodynamic activity in the prefrontal cortex may not necessarily relate to the behavior outcomes of cognitive tasks, which was similar to the previous study's finding during Wisconsin Cart Sort task [34]. Moreover, we only recruited healthy young university students.…”

Section: Discussionsupporting

confidence: 74%

Effects of leaning workstation on oxygenation in the prefrontal cortex and cognitive performance

Kuppam¹,

Kim²,

Penumudi³

et al. 2019

Clin Arch Commun Disord

View full text Add to dashboard Cite

The objective of this study was to evaluate the effect of different workstations on prefrontal brain activity and cognitive performance during standardized neurocognitive tasks.Methods: With a repeated-measures laboratory study, 20 university students (24.5 ± 3.0 years old; 10 females) were exposed to either a conventional sitting workstation or leaning workstation. After a one-hour exposure to the workstation, participants performed five different neurocognitive tasks which assessed the executive function and working memory.Results: The oxygenation levels in the prefrontal cortex were significantly different between the two workstations (p's < 0.042). However, there was no significant difference in cognitive performance (speed and accuracy) between the two workstations (p's > 0.064). Given higher oxygenation concentration in the prefrontal cortex, the leaning workstation might have improved the capacity of executive function and working memory when compared to the sitting workstation. Conclusions:The findings suggest that leaning workstation may improve the cognitive function when compared to sitting workstation by increasing the prefrontal cortex activity associated with the executive function and working memory. This study exposed the potential neurocognitive benefits of the leaning workstation.

show abstract

Section: Discussionsupporting

confidence: 74%

Effects of leaning workstation on oxygenation in the prefrontal cortex and cognitive performance

Kuppam¹,

Kim²,

Penumudi³

et al. 2019

Clin Arch Commun Disord

View full text Add to dashboard Cite

show abstract

“…It is noteworthy that males and females differ significantly during resting state – men demonstrated a higher HbO (Jaušovec and Jaušovec, 2010; Chuang and Sun, 2014). In the present study, the two-way stress and gender interaction in the right lateral PFC with a medium effect size (η p 2 = 0.385) revealed higher HbO in males than females under stress, results consistent with Li et al (2010) and Cinciute et al (2018). Greater HbO in males than females may have been due to increased neuronal activation or differences in brain and morphology (Ruigrok et al, 2014; Choleris et al, 2018).…”

Section: Discussionsupporting

confidence: 71%

Neural Efficiency of Human–Robotic Feedback Modalities Under Stress Differs With Gender

Nuamah

Mantooth

Karthikeyan

et al. 2019

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Sensory feedback, which can be presented in different modalities -single and combined, aids task performance in human-robotic interaction (HRI). However, combining feedback modalities does not always lead to optimal performance. Indeed, it is not known how feedback modalities affect operator performance under stress. Furthermore, there is limited information on how feedback affects neural processes differently for males and females and under stress. This is a critical gap in the literature, particularly in the domain of surgical robotics, where surgeons are under challenging socio-technical environments that burden them physiologically. In the present study, we posited operator performance as the summation of task performance and neurophysiological cost of maintaining that performance. In a within-subject design, we used functional near-infrared spectroscopy to assess cerebral activations of 12 participants who underwent a 3D manipulation task within a virtual environment with concurrent feedback (visual and visual + haptic) in the presence and absence of a cognitive stressor. Cognitive stress was induced with the serial-7 subtraction test. We found that while task performance was higher with visual than visual + haptic feedback, it degraded under stress. The two feedback modalities were found to be associated with varying neural activities and neural efficiencies, and these were stress-and genderdependent. Our findings engender further investigation into effectiveness of feedback modalities on males and females under stressful conditions in HRI.

show abstract

“…Perhaps the relative low number of subjects following stratification by education in each education group prevents us from detecting sex differences in these two scores [ 16 ]. Interestingly, Cinciute et al [ 17 ] identified significant sex-related neuronal activity in the PFC in healthy participants, but behavioral results of the WCST did not show sex bias. This contradiction arises because some functional brain maps of the WCST may be sensitive to neurophysiology heterogeneity which is not apparent or necessarily related to the behavior [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Cinciute et al [ 17 ] identified significant sex-related neuronal activity in the PFC in healthy participants, but behavioral results of the WCST did not show sex bias. This contradiction arises because some functional brain maps of the WCST may be sensitive to neurophysiology heterogeneity which is not apparent or necessarily related to the behavior [ 17 ]. Although the standardization, validity and reliability of WCST as a stand-alone cognitive assessment in healthy adults of various ages and education levels have been established [ 72 ], a battery of cognitive tests is required to unveil the effects of education on different domains of cognition.…”

Section: Discussionmentioning

confidence: 99%

Cholinergic-estrogen interaction is associated with the effect of education on attenuating cognitive sex differences in a Thai healthy population

et al. 2023

View full text Add to dashboard Cite

The development of human brain is shaped by both genetic and environmental factors. Sex differences in cognitive function have been found in humans as a result of sexual dimorphism in neural information transmission. Numerous studies have reported the positive effects of education on cognitive functions. However, little work has investigated the effect of education on attenuating cognitive sex differences and the neural mechanisms behind it based on healthy population. In this study, the Wisconsin Card Sorting Test (WCST) was employed to examine sex differences in cognitive function in 135 Thai healthy subjects, and label-free quantitative proteomic method and bioinformatic analysis were used to study sex-specific neurotransmission-related protein expression profiles. The results showed sex differences in two WCST sub-scores: percentage of Total corrects and Total errors in the primary education group (Bayes factor>100) with males performed better, while such differences eliminated in secondary and tertiary education levels. Moreover, 11 differentially expressed proteins (DEPs) between men and women (FDR<0.1) were presented in both education groups, with majority of them upregulated in females. Half of those DEPs interacted directly with nAChR3, whereas the other DEPs were indirectly connected to the cholinergic pathways through interaction with estrogen. These findings provided a preliminary indication that a cholinergic-estrogen interaction relates to, and might underpin, the effect of education on attenuating cognitive sex differences in a Thai healthy population.

show abstract

Hemodynamic effects of sex and handedness on the Wisconsin Card Sorting Test: the contradiction between neuroimaging and behavioural results

Cited by 7 publications

References 91 publications

Effects of leaning workstation on oxygenation in the prefrontal cortex and cognitive performance

Effects of leaning workstation on oxygenation in the prefrontal cortex and cognitive performance

Neural Efficiency of Human–Robotic Feedback Modalities Under Stress Differs With Gender

Cholinergic-estrogen interaction is associated with the effect of education on attenuating cognitive sex differences in a Thai healthy population

Contact Info

Product

Resources

About