Hemodynamic Evaluation of Type B Aortic Dissection Using Compressed Sensing Accelerated 4D Flow MRI

Abstract

Background 4D Flow MRI is a quantitative imaging technique to evaluate blood flow patterns; however, it is unclear how compressed sensing (CS) acceleration would impact aortic hemodynamic quantification in type B aortic dissection (TBAD). Purpose To investigate CS‐accelerated 4D Flow MRI performance compared to GRAPP‐accelerated 4D Flow MRI (GRAPPA) to evaluate aortic hemodynamics in TBAD. Study Type Prospective. Population Twelve TBAD patients, two volunteers. Field Strength/Sequence 1.5T, 3D time‐resolved cine phase‐contrast gradient echo sequence. Assessment GRAPPA (acceleration factor [R] = 2) and two CS‐accelerated (R = 7.7 [CS7.7] and 10.2 [CS10.2]) 4D Flow MRI scans were acquired twice for interscan reproducibility assessment. Voxelwise kinetic energy (KE), peak velocity (PV), forward flow (FF), reverse flow (RF), and stasis were calculated. Plane‐based mid‐lumen flows were quantified. Imaging times were recorded. Tests Repeated measures analysis of variance, Pearson correlation coefficients (r), intraclass correlation coefficients (ICC). P < 0.05 indicated statistical significance. Results The KE and FF in true lumen (TL) and PV in false lumen (FL) did not show difference among three acquisition types (P = 0.818, 0.065, 0.284 respectively). The PV and stasis in TL were higher, KE, FF, and RF in FL were lower, and stasis was higher in GRAPPA compared to CS7.7 and CS10.2. The RF was lower in GRAPPA compared to CS10.2. The correlation coefficients were strong in TL (r = [0.781–0.986]), and low to strong in FL (r = [0.347–0.948]). The ICC levels demonstrated moderate to excellent interscan reproducibility (0.732–0.989). The FF and net flow in mid‐descending aorta TL were significantly different between CS7.7 and CS10.2. Conclusion CS‐accelerated 4D Flow MRI has potential for clinical utilization with shorter scan times in TBAD. Our results suggest similar hemodynamic trends between acceleration types, but CS‐acceleration impacts KE, FF, RF, and stasis more in FL. Evidence Level: 1 Technical Efficacy: Stage 2

Investigation of effective invasive blood pressure control methods to prevent acute exacerbation of acute aortic dissection

“…One possible reason for the temporal relationship between acute deterioration and hypotension is the vulnerability of the dissected vessel or false lumen and the distribution of blood flow between the true and false lumens. Recently, 4D-flow MRI has been used to evaluate the haemodynamics AAD [18], and a study by Armour et al [19]. using a pig model suggested that an increase in the flow rate in the true lumen is associated with a decrease in wall shear stress around the tear from changes in local velocity, resulting in a decrease in false luminal pressure and the pressure difference between the two lumens, suggesting aortic stabilisation [19].…”

“…One possible reason for the temporal relationship between acute deterioration and hypotension is the vulnerability of the dissected vessel or false lumen and the distribution of blood flow between the true and false lumens. Recently, 4D-flow MRI has been used to evaluate the haemodynamics of AAD [18], and a study by Armour et al . [19].…”

ESPC-BCS-Net: A network-based CS method for underwater image compression and reconstruction

“…With the development of CS and Deep Learning, the networkbased CS methods have been applied to magnetic resonance imaging (Kilinc et al, 2022), acoustic transmission (Atanackovic et al, 2020), and synthetic aperture radar imaging (Cheng et al, 2022). The network-based CS method allows the reconstruction of images quickly once the network has been trained.…”

Aortic Hemodynamics with Accelerated Dual-Venc 4D Flow MRI in Type B Aortic Dissection

“…In our previous study, we investigated the applicability of the CS-accelerated SV 4D flow MRI in TBAD with no impact by the DV methodology [31]. Here, in this study, we aim to systematically evaluate the potential utility of CS-accelerated DV 4D flow MRI with an acceleration level of 7.7 (R = 7.7) in aortic hemodynamics, including KE, PV, forward flow (FF), reverse flow (RF) and flow stasis in a cohort of chronic TBAD patients and volunteers.…”