2022
DOI: 10.3390/cancers14051342
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Hemodynamic Imaging in Cerebral Diffuse Glioma—Part B: Molecular Correlates, Treatment Effect Monitoring, Prognosis, and Future Directions

Abstract: Gliomas, and glioblastoma in particular, exhibit an extensive intra- and inter-tumoral molecular heterogeneity which represents complex biological features correlating to the efficacy of treatment response and survival. From a neuroimaging point of view, these specific molecular and histopathological features may be used to yield imaging biomarkers as surrogates for distinct tumor genotypes and phenotypes. The development of comprehensive glioma imaging markers has potential for improved glioma characterizatio… Show more

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Cited by 9 publications
(5 citation statements)
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“…BOLD imaging contrast is well suited for this technique as it derives from the different physical properties of hemoglobin in its saturated and desaturated state which result in a diamagnetic versus a paramagnetic signal response, respectively ( Buxton, 2013 ; Gauthier and Fan, 2019 ). Perfusion patterns observed in our study are in agreement to what is reported in the literature for different tumor histologies ( Tamrazi et al, 2016 ; Guida et al, 2022 ; Stumpo et al, 2022 ) and display, even if with some spatial differences, remarkably good qualitative agreement with DSC-MRI. To which extent the spatial as well as quantitative differences observed are determined by intrinsic tumor characteristics exhibiting differential response to a contrast medium versus an endogenous deoxyhemoglobin bolus remains to be further investigated in future studies.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…BOLD imaging contrast is well suited for this technique as it derives from the different physical properties of hemoglobin in its saturated and desaturated state which result in a diamagnetic versus a paramagnetic signal response, respectively ( Buxton, 2013 ; Gauthier and Fan, 2019 ). Perfusion patterns observed in our study are in agreement to what is reported in the literature for different tumor histologies ( Tamrazi et al, 2016 ; Guida et al, 2022 ; Stumpo et al, 2022 ) and display, even if with some spatial differences, remarkably good qualitative agreement with DSC-MRI. To which extent the spatial as well as quantitative differences observed are determined by intrinsic tumor characteristics exhibiting differential response to a contrast medium versus an endogenous deoxyhemoglobin bolus remains to be further investigated in future studies.…”
Section: Discussionsupporting
confidence: 91%
“…Perfusion assessment is clinically relevant in brain tumor diagnosis and follow-up, as increased perfusion correlates with tumor’s aggressiveness and can be used in the differential diagnosis of cerebral lesions as well as to distinguish post-treatment changes from tumor recurrence/progression ( Guida et al, 2022 ; Stumpo et al, 2022 ). However, in a proportion of brain tumors the blood brain barrier is either disrupted or dysfunctional (e.g., glioblastomas, metastasis) ( Arvanitis et al, 2020 ; Guan et al, 2021 ), making contrast leakage in the extravascular extracellular space a significant confounder to reliable and reproducible measurements ( Shiroishi et al, 2015 ; Leu et al, 2017 ; Boxerman et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…DCE permeability parameters, including K trans , v p , and v e , have also shown a decrease in the case of IDH mutant gliomas compared to IDH-wild-type. [ 35 36 38 ] On the other hand, the results of studies on the usefulness of ASL-CBF in distinguishing these two types of gliomas are not consistent. [ 38 93 94 ] The study by Yamashita et al .…”
Section: Resultsmentioning
confidence: 99%
“…[ 35 36 38 ] On the other hand, the results of studies on the usefulness of ASL-CBF in distinguishing these two types of gliomas are not consistent. [ 38 93 94 ] The study by Yamashita et al . demonstrated that combination of tumor blood flow obtained from ASL and measurement of necrotic area from routine MRI is a surrogate marker for predicting the IDH1 status in GBM patients.…”
Section: Resultsmentioning
confidence: 99%
“…To determine tumor vascularization profiles in a non-invasive manner at an early stage, magnetic resonance imaging (MRI) and dynamic susceptibility contrast (DSC) play a vital role [ 15 ]. MRI-DSC provides valuable insights into the microvascular characteristics of brain tumors and encompasses crucial parameters, like blood volume and flow, proving invaluable in diagnosis and treatment planning [ 16 , 17 ]. It also aids in determining tumor grade, distinguishing between tumor recurrence and radiation necrosis, and assessing treatment responses [ 18 , 19 ].…”
Section: Introductionmentioning
confidence: 99%