The gasometric analysis offers a formal evaluation in the process of weaning for the mechanical ventilation (MV). Gasometry and clinical symptoms allow the identification of patients who are candidates for a spontaneous breathing test (SBT). The decrease in SvcO 2 ≥ 5.4% and the increase in ∆Pv-aCO 2 ≥ 40%, after 30 minutes of SBT, predict with very good precision failure to remove MV. The oxygenation indices (IsOx) show changes and also change at the end of the SBT and could predict extubation failure, but cut-off points need to be established in pulmonary and non-pulmonary problems.