Hemodynamic responses in rat brain during transcranial direct current stimulation: a functional near-infrared spectroscopy study

Han, Chang Hee; Song, Hyuna; Kang, Yong Guk; Kim, Beop Min; Im, Chang-Hwan

doi:10.1364/boe.5.001812

Cited by 35 publications

(32 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…45 While not involving a form of epilepsy, a study that used NIRS to monitor the hemodynamics responses in rat brains during transcranial direct current stimulation found that the HbO concentration increased almost linearly during this stimulation. 46 In a study of patients with periodic limb movements during sleep, the cerebral hemodynamics varied among the different sleep stages, and there were also changes in the phase differences between HbO and HbR during the different sleep stages in normal controls. 47 The present study has demonstrated the presence of cerebral hemodynamics disturbances in restless leg syndrome patients with periodic limb movements in sleep and suggests that NIRS can be used to determine the cerebral blood flow.…”

Section: Epilepsymentioning

confidence: 99%

“…46 In a study of patients with periodic limb movements during sleep, the cerebral hemodynamics varied among the different sleep stages, and there were also changes in the phase differences between HbO and HbR during the different sleep stages in normal controls. 47 The present study has demonstrated the presence of cerebral hemodynamics disturbances in restless leg syndrome patients with periodic limb movements in sleep and suggests that NIRS can be used to determine the cerebral blood flow.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Application of near-infrared spectroscopy in clinical neurology

Kim

Bae

2018

Ann Clin Neurophysiol

View full text Add to dashboard Cite

Near-infrared spectroscopy (NIRS) monitoring has been used mainly to detect reduced perfusion of the brain during orthostatic stress in order to assess orthostatic intolerance (OI). Many studies have investigated the use of NIRS to reveal the pathophysiology of patients with OI. Research using NIRS in other neurological diseases (e.g., stroke, epilepsy, and migraine) is continuing. NIRS may play an important role in monitoring the regional distribution of the hemodynamic flow in real time and thereby reveal the underlying pathophysiology and facilitate the management of not only patients with OI symptoms but also those with various neurological diseases.Key words: Orthostatic intolerance; Near-infrared spectroscopy; Clinical neurology INTRODUCTIONMany studies have investigated the hemodynamics and functions of the brain in various fields.1 Several noninvasive methods have been introduced in recent decades for measuring neuronal activity in the brain. 2 Neurophysiological techniques such as electroencephalography, magnetoencephalography, and event-related potentials offer the ability to measure overall changes in the electromagnetic field with an excellent time resolution, but these methods have poor spatial resolution. On the other hand, brain imaging techniques such as positron-emission tomography (PET) and functional magnetic resonance imaging (fMRI) have greatly increased our knowledge about neural circuitry. However, PET is highly sensitive to motion artifacts, confines the patient, and involves the injection of radioactive materials. Although fMRI is noninvasive and has excellent spatial resolution, it is expensive, highly sensitive to motion artifacts, and difficult to integrate with other imaging modalities. 3,4 Near-infrared spectroscopy (NIRS) was introduced as a new neuroimaging modality for Principle of NIRSNIRS is a noninvasive optical imaging tool for observing changes in the hemodynamics in the prefrontal area that is based on measuring the concentrations of HbO and HbR in the blood. Since Franz Jöbsis first studied the oxygenation of living tissues, NIRS has been extensively applied in imaging studies of brain activation. 6 The physiological activation of neurons leads to an imbalance between oxygen supply and utilization, increasing the concentration of HbO and decreasing the concentration of HbR. Most tissues are relatively transparent to light in the near-infrared range from 700 to 900 nm, and photons interact with tissues via absorption and scattering. This means that near-infrared light is less absorbed and scattered by tissue than is light at other wavelengths. 7 This range of wavelengths is often called an optical window since the light can easily pass through most tissues; however, it is reflected by HbO and HbR, and hence the absorption and scattering of light used for NIRS can provide information relevant to neural activity. 8 This light penetrates several centimeters through tissue and can still be detected (Fig. 1). The NIRS system consists of a light source and a photodetector. The l...

show abstract

Section: Epilepsymentioning

confidence: 99%

mentioning

confidence: 99%

Application of near-infrared spectroscopy in clinical neurology

Kim

Bae

2018

Ann Clin Neurophysiol

View full text Add to dashboard Cite

show abstract

“…Відомо, що астроцити відіграють важливу роль у регулюванні мозкового кровообігу [7]. Беручи до уваги тісний взаємозв'язок активності нейронів і мозкового кровообігу, очікується, що ТМП має впливати на гемодинаміку, збільшуючи перфузію мозку [8,9]. ТМП може бути використана як окремий терапевтичний метод, так і в поєднанні зі стандартною терапією для коригування збудливості кори головного мозку і покращення рухової активності у пацієнтів із різними неврологічними розладами [10].…”

Section: вступunclassified

Cerebral hemodynamics and electroencephalographic pattern in patients with symptomatic epilepsy at combined treatment with transcranial direct current stimulation

Yatsenko¹

2018

Fiziol Zh

View full text Add to dashboard Cite

Досліджували вплив комплексного лікування з застосуванням транскраніальної мікрополяризації (ТМП) на мозковий кровообіг у 29 пацієнтів, хворих на симптоматичну епілепсію. До порівняльної групи, яким проводили базисні лікувально-реабілітаційні заходи, увійшло 14 дітей, до основної-15 дітей, яким на фоні базисної терапії додатково проводили курс ТМП. Метод транскраніальної допплерографії судин голови використовували для дослідження мозкової гемодинаміки дітей з симптоматичною епілепсією до та після комплексного лікування з застосуванням методу ТМП. Після закінчення курсу транскраніальної мікрополярізації у дітей відзначалося виражене покращення електроенцефалографічної картини, а також вірогідно зменшувалися високі значення середньої швидкості кровообігу за цикл по базилярній артерії (БА), середнім (СМА) та переднім (ПМА) мозковим артеріям (на 20,5, 17,2 та 7,9 % відповідно). У групі порівняння вірогідної позитивної динаміки не спостерігалося. ТМП вірогідно збільшувала низькі значення цього показника по БА, СМА та ПМА (на 25,1, 20,9, 10,2 % відповідно). Статистично вірогідне його зростання на 12,7 % було лише по СМА у пацієнтів групи порівняння. Отримані результати свідчать, що використання ТМП у комплексному лікуванні хворих на симптоматичну епілепсію покращує показники мозкової гемодинаміки у 84 % осіб на відміну від 58 % у групі порівняння. Додавання цього методу у комплексне лікування хворих на симптоматичну епілепсію підвищує ефективність лікування, а також може позитивно впливати на клінічний перебіг захворювання. Ключові слова: транскраніальна допплерографія судин голови; епілепсія; транскраніальна мікрополяризація.

show abstract

“…Fifteen minutes of anodal tDCS at 100 μA increased CBF up to 30 min afterwards, whereas 100 μA of cathodal tDCS decreased CBF by 25% for up to 30 min. Similarly, a functional near-infrared spectroscopy (fNIRS) study on rats also observed an increase in oxygenated hemoglobin during anodal tDCS, which persisted for 30 min afterwards [50]. Whether these physiological effects are a direct result of electric fields (e.g., vessel dilation effects from DC fields- [51,52]) or secondary effects from polarized neurons affecting other cell functions and cascades remains an open question.…”

Section: Animal Modelsmentioning

confidence: 99%

What Effect Does tDCS Have on the Brain? Basic Physiology of tDCS

Jamil¹,

Nitsche²

2017

Curr Behav Neurosci Rep

View full text Add to dashboard Cite

Purpose of the Review Transcranial direct current stimulation (tDCS) can effectively modulate a wide range of clinical and cognitive outcomes by modulating cortical excitability. Here, we summarize the main findings from both animal and human neurophysiology literature, which have revealed mechanistic evidence for the acute and neuroplastic after-effects of tDCS. Recent Findings Insights into the magnitude and geometric orientation of transcranially induced currents have been provided by the combination of computational modeling of current flow in animal slice preparations and intracranial recordings in humans. In addition to its synaptic effects, stimulation also induces after-effects on the glial and vascular systems, the latter also observed in humans by magnetic resonance imaging. Several studies have also observed non-linear or antagonistic effects of tDCS parameters, which warrants further systematic studies to explore and understand the basic mechanisms. Summary tDCS is a valuable and promising technique across the neurophysiological, cognitive neuroscience, and clinical domains of research. Primary and secondary effects of tDCS still remain to be completely understood. An important challenge for the field is advancing tDCS protocols forward for optimal intervention and treatment strategies.

show abstract

Hemodynamic responses in rat brain during transcranial direct current stimulation: a functional near-infrared spectroscopy study

Cited by 35 publications

References 32 publications

Application of near-infrared spectroscopy in clinical neurology

Application of near-infrared spectroscopy in clinical neurology

Cerebral hemodynamics and electroencephalographic pattern in patients with symptomatic epilepsy at combined treatment with transcranial direct current stimulation

What Effect Does tDCS Have on the Brain? Basic Physiology of tDCS

Contact Info

Product

Resources

About