Hemodynamic studies in beriberi heart disease

Akbarian, Mohammed; Yankopoulos, Nicholas A.; Abelmann, Walter H.

doi:10.1016/0002-9343(66)90016-7

Cited by 105 publications

(28 citation statements)

References 30 publications

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“…(This may explain the severe and even fatal metabolic acidosis 22 exhibited by our hospitalized patients.) The only definitive treatment of beriberi is immediate ad- 20 Subsequent to the identification of beriberi at the detention center, several measures were implemented to prevent others from developing disease, and the outbreak ended. Thiamine (100 mg orally) was given to all detainees.…”

Section: Discussionmentioning

confidence: 99%

Outbreak of Beriberi Among Illegal Mainland Chinese Immigrants at a Detention Center in Taiwan

Chen

Twu²,

Chiou³

et al. 2003

Public Health Reports

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Objective. The authors describe an outbreak of beriberi in a detention center in Taiwan and examine risk factors for illness. Methods.A survey was conducted among a sample of 176 randomly selected detainees. A menu-assisted dietary recall method was used to obtain diet information from nine hospitalized detainees. A probable case patient was defined as an individual who had at least two of the following characteristics: leg edema, weakness of the extremities, poor appetite, and dyspnea. Possible case patients were those who had only one of these characteristics.Results. Of the 176 survey respondents, 19% were classified as probable case patients and 40% as possible case patients. The mortality rate based on probable cases was 1.1%. Body Mass Index (BMI) was negatively associated with illness (pϽ0.0001), and length of stay in the detention center was independently positively associated with illness (pϽ0.05). The average intake of dietary thiamine among the nine hospitalized case patients who completed three-day dietary recall surveys was 0.49Ϯ0.1 mg/day. After thiamine administration, all symptoms and signs of beriberi resolved.Conclusion. This outbreak is a reminder of the importance of ensuring adequate diets for poor, institutionalized, or refugee populations who are unable to supplement their diets.

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Section: Discussionmentioning

confidence: 99%

Outbreak of Beriberi Among Illegal Mainland Chinese Immigrants at a Detention Center in Taiwan

Chen

Twu²,

Chiou³

et al. 2003

Public Health Reports

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“…This is in marked contrast to the resistance to methoxamine, even in high dosage, recently encountered in a patient with beriberi heart disease. 37 The acute, immediate reversal of the high output state of anemia by orthostatic stress or by a vasoconstrictor drug indicates that the increased blood flow is primarily mediated by lowered peripheral resistance due to vasodilatation rather than to low blood viscosity,'" " the viscosity presumably remaining unaltered by these acute interventions. Whatever the stimulus for vasodilataton, it is not strong enough to prevent reversal by the endogenous and exogenous vasoconstrictor mechanisms tested.…”

Section: Discussionmentioning

confidence: 99%

The Hemodynamic Response to Chronic Anemia

1969

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“…In those individuals in whom general malnutrition or specific vitamin or protein deficiency are superimposed factors, the onset and course of clinical cardiac disease may be significantly modified. Thiamine treatment in the relatively few patients with a demonstrable deficiency of this vitamin is known to reduce the marked peripheral vasodilation that characterizes the beriberi syndrome (32,33). The consequent reduction of blood flow and volume by diminishing the work-load of the alcoholic heart, may be the major therapeutic action of thiamine, since a demonstrable effect of an isolated thiamine deficiency on myocardial function has not been established (34).…”

Section: Restyltsmentioning

confidence: 99%

Ventricular function in noncardiacs with alcoholic fatty liver: role of ethanol in the production of cardiomyopathy

Regan¹,

Levinson²,

Oldewurtel³

et al. 1969

J. Clin. Invest.

225

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A B S T R A C T Since many patients with cardiomyopathy have a history of chronic ethanolism often associated with malnutrition, we have evaluated left ventricular (LV) function in alcoholics with fatty liver, who had no clinical evidence of cardiac or nutritional disease.During an afterload test of LV function the pressor response to angiotensin evoked a threefold rise of enddiastolic pressure in the alcoholic group which was substantially greater than the 4 mm Hg rise in control subjects. The stroke volume and stroke work response in the noncardiac alcoholic was significantly less than in controls. Diminished LV function was corroborated in the noncardiac alcoholic at rest, using a contractility index.To evaluate the dose-response relationship of ethanol in the production of cardiac malfunction, two groups of noncardiac alcoholic subjects were studied acutely at low and moderate dose levels. After 6 oz, ventricular function, myocardial blood flow, and metabolism were not significantly affected. After 12 oz, there was a progressive rise of end-diastolic pressure and decrease of stroke output at a mean blood alcohol level of 150 mg/ 100 ml, reverting toward control by 4 hr. The coronary effluent transiently evidenced leakage of cell constituents, despite an increase of coronary blood flow, suggesting a direct but reversible cardiac injury. Myocardial extraction of triglyceride was enhanced, whereas FFA uptake was reduced. A possible role of myocardial triglyceride accumulation in heart muscle was considered in pathogenesis.Chronic ingestion of 16 oz of Scotch daily by an alcoholic subject while on a normal diet-produced, after 12 wk, a progressive increase of heart rate and size,

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Hemodynamic studies in beriberi heart disease

Cited by 105 publications

References 30 publications

Outbreak of Beriberi Among Illegal Mainland Chinese Immigrants at a Detention Center in Taiwan

Outbreak of Beriberi Among Illegal Mainland Chinese Immigrants at a Detention Center in Taiwan

The Hemodynamic Response to Chronic Anemia

Ventricular function in noncardiacs with alcoholic fatty liver: role of ethanol in the production of cardiomyopathy

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