Hemodynamic targets during therapeutic hypothermia after cardiac arrest: A prospective observational study

Association between blood pressure and outcomes in patients after cardiac arrest: A systematic review

“…Of the nine studies identified, seven were published as indexed articles, 18,[20][21][22][23][24][25] and two were in abstract form. 27,28 One of the abstracts has since been published in a manuscript form, which was included in this systematic review.…”

“…18 Seven studies 18,20-25 reported comparable study population characteristics with respect to baseline demographics such as age and gender, with the remaining two 26,27 not reporting any demographic information. Two studies did not report the cause of the cardiac arrest, 22,26 four studies excluded specifically traumatic arrests, 20,21,24,25 and three studies excluded patients where the cardiac arrest was not specifically cardiac in origin. 18,23,27 Three studies included only patients with an out-of-hospital cardiac arrest, 18,23,27 while the remaining studies included both in-hospital and out-of hospital cardiac arrest.…”

Critical Care Management Focused on Optimizing Brain Function After Cardiac Arrest

“…One study showed the best survival in patients with a MAP of 76-86 mmHg and mixed venous oxygen saturation (SVO2) of 67-72%. 48 Another observa-organs are still at risk. 76 77 It may therefore be rational to maintain PEEP as low as possible as long as higher concentrations of oxygen can be avoided.…”

Improving Survival From Cardiac Arrest: A Review of Contemporary Practice and Challenges

“…75,76 Observational studies have found that a higher mean arterial pressure early after return of spontaneous circulation is associated with better neurologic outcomes, up to 80 to 100 mm Hg; there is no evidence that increasing vasopressor doses to achieve a higher mean arterial pressure is beneficial. 78,83 Central venous and arterial lines are indicated for most patients to allow hemodynamic monitoring and serial lactate measurements.…”

“…Central venous oxygen saturation can be used as a surrogate measure of cardiac output in patients with organ hypoperfusion after cardiac arrest. 83 Echocardiography can exclude persistent precipitating pathologic issues in patients who are hypotensive after return of spontaneous circulation, including pericardial effusion or evidence of pulmonary embolism. Echocardiography often shows left ventricular systolic dysfunction, but echocardiographic abnormalities do not consistently predict vasopressor requirements or outcomes.…”