Hemodynamics of Renal Arterial Diseases and Hypertension

Ed, Frohlich; Ulrych, M; Rc, Tarazi; Hp, Dustan; Ih, Page

doi:10.1097/00000441-196801000-00007

Cited by 21 publications

(6 citation statements)

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“…1 These investigations indicated the importance of the vascular wall, including that of veins. [1][2][3] Freis 1 emphasized aortic stiffness, and Tarazi et al 4 suggested measuring this stiffness using the ratio of pulse pressure to stroke volume. However, more recent studies concerned with large arteries in hypertension have focused on 3 more recent observations.…”

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confidence: 99%

Recent Advances on Large Arteries in Hypertension

et al. 1998

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Abstract-The most classic hemodynamic concept explaining the increased mean arterial pressure in hypertension reflects an increased total peripheral resistance dynamically and an increased wall-to-lumen ratio to suppress smaller arteries. However, a more current consideration takes into account not only that steady component but also the pulsatile component of blood pressure, a point that importantly modifies the traditional hemodynamic definition. Whereas mean arterial pressure is almost constant along the arterial tree, the pulse pressure increases markedly from the more central to the peripheral arteries, indicating that in vivo each artery should be characterized according to its own blood pressure curve. This important concept implies major modifications in the methods used to investigate the relationships between mechanical factors and large artery structure and function. It therefore seems reasonable that in hypertension the large arteries should no longer be considered as passive conduits but rather in terms of their active behavioral response to the mechanical forces to which they are subjected. New investigational aspects in hypertension therefore now involve not only genetic, cellular, and molecular mechanisms but also transductional hemodynamic mechanisms reflecting changing patterns in the extracellular matrix that influence structural remodeling of the vessels. (Hypertension. 1998;32:156-161.)

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confidence: 99%

Recent Advances on Large Arteries in Hypertension

et al. 1998

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“…Therefore, it would seem that the elevation in output is probably just a phase in the development of hypertension rather than being causative in the eventual development of hypertension. Such findings of a hyperkinetic circulation with raised cardiac output have also been described in association with acute glomerular nephritis (de Fazio et al, 1959) and with renovascular hypertensive states (Widimsky et al, 1957;Frohlich et al, 1968;Tarazi et al, 1969;Ulrychs et al, 1969).…”

Section: Resultsmentioning

confidence: 73%

Central circulatory responses in normotensive and hypertensive pregnancy

Lees

1979

Postgraduate Medical Journal

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In patients who become hypertensive as a result of pregnancy, there are marked individual patterns. These different groups show patients with elevated levels of cardiac output, patients with a pure elevation of systemic vascular resistance, and a third group in which there is elevation of both resistance and output.It seems certain that different syndromes are occurring, the theoretical explanations for which are discussed.

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“…Several years ago we described a group of patients with renal arterial disease, having either fibrosing or atherosclerotic lesions, in which the increased arterial pressure was associated not only with an increased heart rate, cardiac index, and left ventricular ejection rate, but with an increased vascular resistance. 3, 36 We have reported subsequently a group of six patients who were studied before and following surgical correction of the renal arterial lesion, and observed that with correction of the arterial lesion there was a normalization of vascular resistance although cardiac output did not change consistently. 37 We have explained these phenomena on the basis that the increased cardiac output was part of the overall pathophysiological alterations involving the total cardiovascular system and that it was not essential for the maintenance of the increased pressure; it was related to the same factors which increased vascular resistance, and thereby the elevated arterial pressure.…”

Section: Hypertensive Hyperkinetic Circulatory Statesmentioning

confidence: 99%

High Cardiac Output Hypertensions

Fröhlich

1976

Angiology

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Hyperkinetic circulation, as it is related to the clinical hypertensive diseases, is defined and its implications interpreted. These pathophysiological considerations have an important bearing in understanding the pressor mechanisms underlying hypertension and the application of therapy. Another very important consideration is the value of elucidating the mechanisms for the hyperdynamic circulation, for with a clearer understanding of these, we shall come closer to an explanation of the pathogenesis of hypertension.

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Hemodynamics of Renal Arterial Diseases and Hypertension

Cited by 21 publications

References 0 publications

Recent Advances on Large Arteries in Hypertension

Recent Advances on Large Arteries in Hypertension

Central circulatory responses in normotensive and hypertensive pregnancy

High Cardiac Output Hypertensions

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