Hemodynamics of revascularization of the corpora cavernosa in an animal model

Floth, Andreas; Paick, Jae‐Seung; Suh, Jung Kook; Lue, Tom F.

doi:10.1007/bf00299058

Cited by 13 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The finding of a statistically significant twofold increase of endothelial nitric oxide synthase messenger RNA expression the day after creation of a fistula between the abdominal aorta and inferior vena cava in male rats may support this hypothesis [15]. Additionally, improvement in intracavernous pressure by retrograde arterial inflow into the cavernous bodies through the collateral deep dorsal venous network may allow retrograde arterial filling of the cavernous bodies and may cause reduction of venous leak [16]. On the other hand, whether or not this increased intracorporeal pressure could lead to smooth muscle damage is not known.…”

Section: Discussionmentioning

confidence: 55%

Is deep dorsal vein arterialization effective in elderly patients?

2007

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 55%

Is deep dorsal vein arterialization effective in elderly patients?

2007

View full text Add to dashboard Cite

show abstract

“…The finding of a statistically two-fold increase of endothelial nitric oxide synthase messenger RNA expression the day after creation of a fistula between the abdominal aorta and inferior vena cava in male rats may support this hypothesis [29]. Additionally, improvement in intracavernosal pressure by retrograde arterial inflow into the cavernosal bodies through the collateral deep dorsal venous network may allow arterial filling of the cavernosal bodies and reduction of venous leak [30]. The smooth muscle restoration of cavernosal tissue after penile revascularization was, however, shown by recording an increase in amplitude and relaxation parameters in the CC-EMG [31].…”

Section: © 2 0 11 T H E a U T H O R S 11 2 B J U I N T E R N A T I O mentioning

confidence: 86%

Penile revascularization in vasculogenic erectile dysfunction (ED): long‐term follow‐up

Kayıgίl¹,

Okulu²,

Aldemir³

et al. 2011

BJU International

View full text Add to dashboard Cite

Study Type – Therapy (case series)Level of Evidence 4What’s known on the subject? and What does the study add?This study reflects the second largest series of revascularization operations performed in different etiologic and risk groups with the longest follow up. Beyond that this is the only study in which CC‐EMG techniques were used preoperatively to exclude some patients and to predict postoperative success in penile revascularization.OBJECTIVE• To determine the overall long‐term success of penile revascularization surgery in the treatment of vasculogenic erectile dysfunction (ED) and also to investigate the effect of risk factors on the results of a modified Furlow–Fisher technique.PATIENTS AND METHODS• Between 1999 and 2010, 125 men with a mean (sd, range) age of 43.2 (11.3, 23–69) years underwent penile revascularization surgery. In all, 110 men completed the long‐term follow‐up with a mean follow‐up of 73.2 months.• Diagnostic evaluations, penile colour Doppler ultrasonography, corpus cavernosum electromyography, and cavernosometry, were performed in all the men before surgery.• The efficacy of the surgery was assessed as improvement or failure according to the change in the five‐item version of the International Index of Erectile Function (IIEF‐5). A ≥5 point increase in the IIEF‐5 score during the latest patient visit after surgery compared with that before surgery was regarded as improvement (surgical success).RESULTS• The mean (sd) IIEF‐5 score was 7.3 (3.2) before surgery and at the end of the follow‐up periodit was 16.8 (3.1).• The success rates were 81.8% at 3 months, 77.2% at 1 year, 70% at 2 years, 66.3% at 3 years and 63.6% at 5 years after surgery in the men who achieved a no‐ED threshold score of >26 in the IIEF‐15.• The success rate was the highest in the men with no risk factors (92.8%).• Seven patients (6.36%) showed signs of glans hypervascularization as a major complication.CONCLUSIONS• Penile revascularization surgery has not been widely used by urologists probably due to the technical difficulties and the use of phosphodiesterase type 5 inhibitors.• However, with reported high rates of noncompliance or failure of oral pharmacotherapy it seems likely that this surgery will become more popular in the near future.

show abstract

“…However, the only experimental study on postoperative flow characteristics in an animal model could not detect neo‐arterial flow in the dorsal arteries. All of the neo‐arterial runoff went into the venous system [12].…”

Section: Definition Of Penile Revascularizationmentioning

confidence: 99%

“…However, there is no study in peer‐reviewed journals, which objectively proved enhanced arterial inflow into the corpora after these procedures [5]. In the animal model, an intracorporal pressure rise could only be demonstrated after creation of an artificial window between the arterialized dorsal vein and the corpus cavernosum [12].…”

Section: Definition Of Penile Revascularizationmentioning

confidence: 99%

Standard Operating Procedures for Vascular Surgery in Erectile Dysfunction: Revascularization and Venous Procedures

Sohn

Hatzinger

Goldstein

et al. 2013

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Introduction The impact of penile blood supply on erectile function was recognized some 500 years ago. At the turn of the 20th century first results of penile venous ligation were published and in 1973 the first surgical attempts to restore penile arterial inflow were undertaken. Numerous techniques were published in the meantime, but inclusion criteria, patient selection, and success evaluation differed extremely between study groups. Aim To develop evidence-based standard operating procedures (SOPs) for vascular surgery in erectile dysfunction, based on recent state of the art consensus reports and recently published articles in peer-reviewed journals. Methods Based on the recent publication of the consensus process during the 2009 International Consultation on Sexual Medicine in Paris, recommendations are derived for diagnosis and surgical treatment of vascular erectile dysfunction. In addition several recent publications in this field not mentioned in the consensus statements are included in the discussion. Main Outcome Measure The Oxford system of evidence-based review was systematically applied. Due to the generally low level of evidence in this field expert opinions were accepted, if published after a well-defined consensus process in peer-reviewed journals. Results Referring to penile revascularization it may be concluded, that in the face of missing randomized trials, only recommendations grade D may be given: this kind of surgery may be offered to men less than 55 years, who are nonsmokers, nondiabetic, and demonstrate isolated arterial stenoses in the absence of generalized vascular disease. The evidence level for recommendations concerning penile venous ligations may be even lower. Too many unsolved controversies exist and universal diagnostic criteria for patient selection as well as operative technique selection have not been unequivocally established. This kind of surgery is still considered investigational but may be offered in special situations on an individualized basis in an investigational or research setting after obtaining written consent, using both pre- and postoperatively validated measuring instruments of success evaluation. Conclusions SOPs for penile revascularization procedures can be developed, concerning a highly selected patient group with isolated arterial stenoses. Based on the available data it is not yet possible to define SOPs for surgical treatment of corporal veno-occlusive dysfunction.

show abstract

Hemodynamics of revascularization of the corpora cavernosa in an animal model

Cited by 13 publications

References 7 publications

Is deep dorsal vein arterialization effective in elderly patients?

Is deep dorsal vein arterialization effective in elderly patients?

Penile revascularization in vasculogenic erectile dysfunction (ED): long‐term follow‐up

Standard Operating Procedures for Vascular Surgery in Erectile Dysfunction: Revascularization and Venous Procedures

Contact Info

Product

Resources

About