Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis
Siyuan Cheng,
Ivan Fan Xia,
Renate Wanner
et al.
Abstract:Brain arteries are wrapped by vascular smooth muscle cells (VSMCs). Fully differentiated VSMCs are important for brain artery homeostasis, and they are lost in several cerebrovascular diseases. How healthy VSMCs differentiate on different brain arteries during development is unclear. Such knowledge will help regenerate lost VSMCs in brain arteriopathy. To answer this question, we studied the developmental muscularization of the zebrafish circle of Willis (CW) arteries, the major arterial loop that supplies blo… Show more
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