Hemodynamics study of a multilayer stent for the treatment of aneurysms

Xiong, Yan; Wang, Xuhong; Jiang, Wentao; Tian, Xiaofeng; Wang, Hongtao; Fan, Yubo; Chen, Yu

doi:10.1186/s12938-016-0248-0

Cited by 9 publications

(8 citation statements)

References 22 publications

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“…Recently, interest in MS has increased significantly as a result of its success in clinical application. However, as previous numerical simulations found that two-layer stents had little impact on the pressure on the aneurysm wall 16 , combinations of SG and MS were presented to obtain better isolation, but the coverage of SG still confuses doctors during the intraoperative period.…”

Section: Discussionmentioning

confidence: 95%

Stent graft coverage of dual-stent strategy in the management of abdominal aortic aneurysms

Yuan

Jiang

et al. 2018

Sci Rep

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Treating an abdominal aortic aneurysm (AAA) with a stent graft (SG) and a multilayer stent (MS) is a key technology in isolating flow fields. Clinically, dual stents (an SG in the proximal and an MS in the distal of AAA) are used for treatment of AAA, but only a few studies have examined the relationship between SG coverage and treatment effects. Through numerical simulation of the hemodynamics after SG and MS implantation, the SG coverage and position were simulated at 0% (0 mm), 25% (13.75 mm), 50% (27.5 mm), and 75% (41.25 mm). With increasing SG coverage, the pressure on the aneurysm sac wall and the flow of branch vessels gradually decreased, and the lower wall shear stress (WSS) gradually increased. The changes in pressure, lower WSS, and the mass flow rate of the branch vessels did not change significantly. The coverage of the SG has a nonsignificant effect on hemodynamics in the treatment of AAA; the implantation position need not be very precise. This research can provide theoretic support for clinicians’ decision-making.

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Section: Discussionmentioning

confidence: 95%

Stent graft coverage of dual-stent strategy in the management of abdominal aortic aneurysms

Yuan

Jiang

et al. 2018

Sci Rep

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“…These are 3-layer stents designed to laminate the flow through the aneurysm so that it gradually becomes thrombotic without affecting the flow in the branches, simultaneously decreasing the peak stress on the aneurysm wall. 4 This feature is particularly important in the aortic arch and thoracoabdominal region.…”

Section: Introductionmentioning

confidence: 99%

Long-term outcome of multilayer flow modulator in aortic aneurysms

Pintaric,

Boltezar,

Umek

et al. 2024

Radiology and Oncology

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Background This retrospective study investigated the efficacy of endovascular treatment with multilayer flow modulators (MFMs) for treating aortic aneurysms in high-risk patients unsuitable for conventional treatments. Patients and methods Conducted from 2011 to 2019 at a single center, this retrospective observational study included 17 patients who underwent endovascular treatment with MFMs. These patients were selected based on their unsuitability for traditional surgical or endovascular procedures. The study involved meticulous pre-procedural planning, precise implantation of MFMs, and follow-up using CT angiography. The primary focus was on volumetric and flow volume changes in aneurysms, along with traditional diameter measurements. Moreover, the technical success and post-procedural complications were also registered. Results The technical success rate was 100%, and 30-day procedural complication rate was 17.6%. Post-treatment assessments revealed that 11 out of 17 patients showed a decrease in flow volume within the aneurysm sac, indicative of a favorable hemodynamic response. The median decrease in flow volume was 12 ml, with a median relative decrease of 8%. However, there was no consistent reduction in aneurysm size; most aneurysms demonstrated a median increase in volume for 46 ml and median increase in diameter for 18 mm. Conclusions While MFMs offer a potential alternative for high-risk aortic aneurysm patients, their effectiveness in preventing aneurysm expansion is limited. The results suggest that MFMs can provide a stable hemodynamic environment but do not reliably reduce aneurysm size. This underscores the need for ongoing vigilance and long-term monitoring in patients treated with this technology.

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“…With the help of CFD and MRI/CT images, the formation of atherosclerotic lesions can be accurately predicted, and haemodynamic parameters can be assessed [19]. Feasibility of incorporating data obtained from CT/MRI in numerical studies is demonstrated in [20]. A potential risk factor of artery geometry resulting in exaggerated atherosclerosis was investigated [21].…”

Section: Introductionmentioning

confidence: 99%

CFD Analysis on Effect of Angulation in A Healthy Abdominal Aorta-Renal Artery Junction

Hegde

Shenoy

Khader

et al. 2021

ARFMTS

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The recent developments in computational fluid dynamics (CFD) can be useful in observing the detailed haemodynamics in renal artery bifurcation for clinical evaluation and treatment. The present study focuses on haemodynamic behaviour of blood as it flows through the abdominal aorta-renal artery junction in an idealistic healthy artery with varying bifurcation angles to the abdominal aorta, i.e. from 30° to 90° with increments of 15°. This is to examine the effect of angulation on the junction and to determine whether arterial geometry plays a role in the prediction of atherosclerotic lesions. The three-dimensional models used in this study were generated using ANSYS WORKBENCH 19.0, and numerical simulation was done using FLUENT 19.0 solver. The blood flow is assumed to be Newtonian, incompressible and laminar. Haemodynamic parameters such as velocity, wall pressure and wall shear stress along with flow variation are compared among the different models. As the angulation increased, velocity and wall shear stress at the ostial region decreased by 14% and 52% respectively. Wall pressure at the same region saw an increase by 3%. Therefore, renal arteries with higher bifurcating angles to the abdominal aorta were observed to be more prone to the formation of atherosclerotic lesions. The present study is a precursor for future studies on renal artery with stenosis.

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Hemodynamics study of a multilayer stent for the treatment of aneurysms

Cited by 9 publications

References 22 publications

Stent graft coverage of dual-stent strategy in the management of abdominal aortic aneurysms

Stent graft coverage of dual-stent strategy in the management of abdominal aortic aneurysms

Long-term outcome of multilayer flow modulator in aortic aneurysms

CFD Analysis on Effect of Angulation in A Healthy Abdominal Aorta-Renal Artery Junction

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