Hemodynamics, Tolerability, and Pharmacokinetics of Linsidomine (SIN-1) Infusion During the Acute Phase of Uncomplicated Myocardial Infarction

A comparative study of the effects of two nitric oxide synthase inhibitors and two nitric oxide donors on temporary focal cerebral ischemia in the Wistar rat

“…1,10 One of the two NO donors used in this study, SIN-1, is routinely used in interventional cardiology as a coronary artery bolus injection. 18 In a study by Shukla, et al, 46 SIN-1 was shown to cross the blood-brain barrier in rats. Nitric oxide formation from SIN-1 occurs spontaneously and does not require the presence of cysteine.…”

Effects of the nitric oxide donor 3-morpholinosydnonimine (SIN-1) in focal cerebral ischemia dependent on intracellular brain pH

“…The NO donor SIN-1 is currently used in interventional cardiology because it produces antispastic and vasodilatory effects without inducing tolerance. 17 In human acute coronary syndromes, titration of SIN-1 to the desired antiisch-emic effect was suggested to lie within the flow rate of 0.2 and 1.6 mg/hour, and titration to the desired vasodilatory effect, without untoward action on filling pressures, cardiac index, or heart rate was said to lie with doses of approximately 1 mg/hour. Comparing these suggested dosages with the dosages used in the present study and in other animal studies 39,50,51,52 we have to conclude that the amounts used in this study-0.1 and 1 mg/kg in rats weighing between 300 and 450 g-are relatively high doses.…”

“…44 The NO donor SIN-1 is currently being used in interventional cardiology to minimize myocardial infarction. 17 Treatment by NO donors in different animal studies has shown a trend toward neuroprotection; 11,13,30,39,[50][51][52] however, isoenzyme-and concentration-dependent dual mechanisms have been proposed to explain both protective and detrimental effects of nonselective inhibitors of NOS at different dosages. 15 Hecker, et al, 22 demonstrated that the activities of endothelial and NOS enzymes 23 were dependent on pH.…”