2019
DOI: 10.1212/wnl.0000000000008003
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Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

Abstract: ObjectiveTo determine the long-term association of hemoglobin levels and anemia with risk of dementia, and explore underlying substrates on brain MRI in the general population.MethodsSerum hemoglobin was measured in 12,305 participants without dementia of the population-based Rotterdam Study (mean age 64.6 years, 57.7% women). We determined risk of dementia and Alzheimer disease (AD) (until 2016) in relation to hemoglobin and anemia. Among 5,267 participants without dementia with brain MRI, we assessed hemoglo… Show more

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Cited by 89 publications
(82 citation statements)
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“…This may be due to differences in the proportions of patients with moderate to severe dementia in the ad group between the two studies; the severity of ad increases the risk of malnutrition, leading to a decrease in plasma cholesterol levels (54,55). in addition, the results of the present study demonstrated that Hb levels in male patients with ad were reduced, consistent with a previous study which suggested that abnormal Hb levels may result in differences in white matter integrity and cerebral perfusion (56).…”
Section: Discussionsupporting
confidence: 93%
“…This may be due to differences in the proportions of patients with moderate to severe dementia in the ad group between the two studies; the severity of ad increases the risk of malnutrition, leading to a decrease in plasma cholesterol levels (54,55). in addition, the results of the present study demonstrated that Hb levels in male patients with ad were reduced, consistent with a previous study which suggested that abnormal Hb levels may result in differences in white matter integrity and cerebral perfusion (56).…”
Section: Discussionsupporting
confidence: 93%
“…In elderly, anemia or abnormal Hb concentrations are associated with higher morbidity and mortality, and with an increased risk for dementia and rapid cognitive decline [265].…”
Section: Iron and Alzheimer's Diseasementioning
confidence: 99%
“…Epidemiologic studies have suggested strong associations between anemia, decline of cognitive function, and AD, with an inverse relationship noted between Hb and AD (145)(146)(147). Moreover, in a large population-based study, it has been shown that low Hb levels are associated with increased long-term risks of dementia (34%) and AD (41%) (148).…”
Section: Alzheimer's Diseasementioning
confidence: 99%