Hemoglobin and hip fracture risk in older non-Hispanic white adults

Looker, Anne C.

doi:10.1007/s00198-014-2769-3

Cited by 20 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 30 Another also suggested low and high hemoglobin values were associated with increased hip fracture risk. 31 The conclusions of the above studies are generally consistent with the results of this study. Conversely, a longitudinal study in older adults did not support the hypothesis that hemoglobin levels are associated with BMD, 21 possibly due to differences in race, age, inclusion and exclusion criteria.…”

Section: Discussionsupporting

confidence: 88%

Association Between Hemoglobin Levels and Osteoporosis in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Ye¹,

Lu²,

Guo³

et al. 2022

DMSO

View full text Add to dashboard Cite

Purpose To explore the relationship between hemoglobin levels and osteoporosis and the risk factors for osteoporosis in patients with type 2 diabetes mellitus (T2DM). Patients and methods A cross-sectional study was conducted in 495 T2DM adults. Medical data were collected from electronic medical records. Results T2DM patients with osteoporosis had significant lower hemoglobin levels (P < 0.001). Spearman correlation analysis and logistic regression analysis showed that age, female, body mass index (BMI), smoking, drinking and hemoglobin levels were significantly associated with osteoporosis in T2DM patients (all P < 0.05). After adjustment for BMI, diabetic duration, estimated glomerular filtration rate (eGFR), smoking and drinking, a significant association between hemoglobin levels and osteoporosis was observed in T2DM males aged 50 years and older (odds ratio [OR] = 0.978, 95% confidence interval [CI]: 0.958–0.998, P = 0.030). Compared to Q3 groups with normal hemoglobin levels, Q1 groups with anemia had an odd of osteoporosis increased 2.9-fold in T2DM men after adjustment for age, BMI, diabetic duration, eGFR, smoking and drinking (P = 0.032). Conclusion Hemoglobin levels were associated with the presence of osteoporosis in T2DM men, especially in those aged 50 years and older.

show abstract

Section: Discussionsupporting

confidence: 88%

Association Between Hemoglobin Levels and Osteoporosis in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Ye¹,

Lu²,

Guo³

et al. 2022

DMSO

View full text Add to dashboard Cite

show abstract

“…Besides, from clinical and nutritional standpoints, good nutritional status often means a good exercise of skeletal muscles, which prevents fracture in these patients. Unexpectedly, we found that higher hemoglobin levels in the FF group may be explained in this way: hyperhemoglobinemia often means increased blood viscosity, which results in endotheliocyte damage and micro-inflammatory state, thus affecting bone metabolism [33]. In fact, it was reported that hypohemoglobinemia and hyperhemoglobinemia are both associated with increased risk of fracture.…”

Section: Discussionmentioning

confidence: 99%

Factors and Outcome of Renal Osteodystrophy-Associated Initial Fragility Fracture in End-Stage Renal Disease Patients

et al. 2019

View full text Add to dashboard Cite

Background: Renal osteodystrophy has caused increased risk of fragility fracture in end-stage renal disease (ESRD) patients. However, risk factors and outcome of ESRD patients with fragility fracture remain uncharacterized. We aimed to assess these parameters in ESRD patients. Summary: This retrospective case-control study analyzed 354 ESRD patients (initial fragility fracture [FF] group, n = 59; control group, n = 295). Pre-dialysis blood hemoglobin, serum albumin, lipid, calcium, phosphorus, alkaline phosphatase (ALP), and intact parathyroid hormone (iPTH) were collected. All procedures performed involving human participants were in accordance with the ethical standards of the institutional committee of The First Affiliated Hospital of Chongqing Medical University (IRB approval number 216-82), and informed consent was obtained from all participants. There were higher prevalence rates of primary hypertension and diabetes, higher serum ALP, corrected calcium, and lower serum total cholesterol, low-density lipoprotein, lipoprotein-α, and iPTH in the FF group. Fractures were more likely to occur in the higher level of corrected calcium as well as in the lower iPTH group. High corrected calcium (p = 0.010, OR = 11.308, 95% CI: 1.770–72.242) and serum ALP (p = 0.000, OR = 1.007, 95% CI: 1.004–1.011) were independent risk factors of fragility fracture. The incidence of all-cause mortality and cardiovascular (CV) events in ESRD patients with fragility fracture was higher than in those without fracture. Key Messages: Patients with hypertension, diabetes, excessive suppression of PTH, and poor nutritional status are more prone to fractures. Serum corrected calcium and ALP were independent risk factors of fragility fracture. Patients with initial fragility fracture had more CV events and higher mortality.

show abstract

“…Most reported that anemia was related to increased risk of fractures, but that risk differed by sex and fracture site, such as vertebral or nonvertebral fractures. In addition, each study included different ethnic groups . A study of adults aged 55 to 74 years in Norway showed that men with anemia were at 2.15‐fold higher risk of nonvertebral fractures than men with high hemoglobin levels (15.2 to 18.8, g/dL) but that women with anemia did not have increased nonvertebral fracture risk .…”

Section: Introductionmentioning

confidence: 99%

Anemia and Risk of Fractures in Older Korean Adults: A Nationwide Population-Based Study

Lee

Shin

Yoo

et al. 2019

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Anemia is a common health problem in older adults and is associated with risk factors for fracture such as low physical function and low bone mass. The aim of this study was to examine the relationship between anemia and fracture risk in older adults. We conducted a retrospective cohort study from 2003 to 2013. The participants were community-dwelling Korean adults aged 65 years and older who participated in the National Health Screening Program (n ¼ 72,131) between 2003 and 2008. Anemia (<12 g/dL for women and <13 g/dL for men) and severity of anemia (mild: 11 g/dL Hb < 12 g/dL; moderate to severe: Hb < 11 g/dL) were defined by World Health Organization (WHO) criteria. The incidence of any fractures, vertebral fractures, and femur fractures was identified using ICD-10 codes. Cox proportional hazard regression models were used to assess risk of fracture according to anemia. Anemia was associated with increased risk of fracture in men (any: adjusted hazard ratio [aHR] ¼ 1.29, 95% confidence interval [CI] 1.18-1.41; vertebral: aHR ¼ 1.20, 95% CI 1.03-1.40; femur: aHR ¼ 1.71, 95% CI 1.44-2.04), and less strongly but still significantly in women (any: aHR ¼ 1.10, 95% CI 1.11-1.41; vertebral: aHR ¼ 1.11, 95% CI 1.03-1.20; femur: aHR ¼ 1.37, 95% CI 1.25-1.52). Higher risk was observed in subjects with moderate-to-severe anemia in both sexes. Considering the high prevalence of anemia in older adults, it is important that health professionals recognize increased fracture risk in older adults with anemia.

show abstract

Hemoglobin and hip fracture risk in older non-Hispanic white adults

Cited by 20 publications

References 34 publications

Association Between Hemoglobin Levels and Osteoporosis in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Association Between Hemoglobin Levels and Osteoporosis in Chinese Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study

Factors and Outcome of Renal Osteodystrophy-Associated Initial Fragility Fracture in End-Stage Renal Disease Patients

Anemia and Risk of Fractures in Older Korean Adults: A Nationwide Population-Based Study

Contact Info

Product

Resources

About