Hemoglobin and serum ferritin levels in women using copper-releasing or levonorgestrel-releasing intrauterine devices: a systematic review

Lowe, Richard F.; Prata, Ndola

doi:10.1016/j.contraception.2012.09.025

Cited by 38 publications

(24 citation statements)

References 37 publications

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“…In contrast, a longitudinal prospective study conducted among Iranian women found that there was no significant increase in anaemia cases among copper-IUD users (32). A recent meta-analysis of studies that measured haemoglobin changes among copper-IUD users found significant decreases of haemoglobin level after one year of use, but these changes were not sufficient to induce anaemia in women with no history of anaemia (33). Another systematic review found no significant changes of haemoglobin level among anaemic women who used copper-IUD for up to one year (34).…”

Section: Discussionmentioning

confidence: 92%

Prevalence and risk factors of anaemia among ever-married women in Jordan

Arabyat

Al-Taani

2019

East Mediterr Health J

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Background: Anaemia is associated with poor health outcomes and is considered a serious public health problem particularly in low-and middle-income countries. Specific subgroups are at higher risk of anaemia, such as women of reproductive age. Aims: This study examined the prevalence and risk factors of anaemia among ever-married women in Jordan using a secondary analysis of the Jordan Population and Family Health Survey. Methods: This is a secondary analysis of data from a nationally representative sample of ever-married women aged 15-49 years that were tested for haemoglobin levels in the 2012 JPFHS. Anaemia was categorized according to the WHO criteria. Univariate and multivariate logistic regression analyses were used to investigate risk factors associated with anaemia. Results: The prevalence of any anaemia was 37.3%; specifically, 20% had mild anaemia (haemoglobin 11.0-11.9 g/dl), 16.3% had moderate anaemia (hemoglobin 8.0-10.9 g/dl) and 1% had severe anaemia (haemoglobin < 8.0 g/dl). Factors that were associated with anaemia in the multivariate regression included urban women (P = 0.01), living in the north (P = 0.014) or south regions (P = 0.013) of Jordan, having multiple children (P < 0.001), being pregnant (P < 0.01), and using IUD as a contraceptive method (P < 0.001). Conclusions: A high prevalence of anaemia among ever-married women of reproductive age in Jordan was noticed. The results emphasize the importance of urgent public health interventions to prevent anaemia in Jordan, particularly among high-risk subgroups.

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Section: Discussionmentioning

confidence: 92%

Prevalence and risk factors of anaemia among ever-married women in Jordan

Arabyat

Al-Taani

2019

East Mediterr Health J

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“…The increased hemoglobin and hematocrit levels that we observed in both OAT users and non-users were consistent with previous findings [11,17,23] and were associated with an LNG-IUS-induced reduction in menstrual flow [10]. Approximately 73% of the women in the 2 groups experienced amenorrhea or infrequent bleeding over the 12-month period.…”

Section: Discussionsupporting

confidence: 92%

“…POCs do not increase the risk of thrombosis [8,9], and they tend to reduce the volume of menstrual bleeding [10]. In contrast, a copper IUD can increase menstrual bleeding and the risk of anemia [11,12], which can be a particular problem for women using OAT.…”

Section: Introductionmentioning

confidence: 99%

Efeito do uso de anticoagulante oral sobre o padrão de sangramento associado ao uso do sistema intrauterino liberador de levonorgestrel em mulheres portadoras de trombofilia e/ou com passado de trombose

Braga¹

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Às mulheres que participaram do estudo como voluntárias, que depositaram confiança e colaboração para este trabalho. À minha amiga irmã, Karolina Avelino, cujo carinho me incentiva a realizar meus sonhos mesmo estando distante de todos os mais próximos. Aos meus amigos, Karina Xavier, Marcos Oliveira, Olivia Gomes e Andrei Correia, que fazem minha vida mais feliz por conhecê-los e compartilhar os momentos juntos de maneira leve e feliz. As amigas, Renata Paixão e Ana Paula Rangel, que mesmo distantes sinto o carinho e força para me fazer perseverar. Tenho muito orgulho das profissionais e pessoas que nos tornamos dentre todas as dificuldades. À amiga, Adriana Leão, que foi uma peça chave para eu realizar este sonho de ser Mestre, cujo carinho e confiança me ajudaram a iniciar essa jornada acadêmica. A amiga, Milena Bastos Brito, que me ajudou na realização desse trabalho de forma pessoal, carinhosa e muito generosa. Aos meus familiares que sempre estiveram perto apesar da distância. À amiga, Océlia de Vasconcelos, auxiliar do Setor de Pesquisa Clínica, que me ajudou na evolução deste trabalho, enchendo os meus caminhos de Luz e boas energias. À Comissão de Pós-graduação em Tocoginecologia, pela oportunidade de fazer minha pósgraduação neste setor, o que é motivo de muito orgulho para mim. Ao Professores Doutores: Rui Ferriani, Paula Navarro e Ana Carolina de Sá, que através da primeira aula de Metodologia me fizeram perceber que estava no lugar certo. À Suelen Bezerra, secretária da pós-graduação em Tocoginecologia, pela amizade, competência e paciência comigo, sempre disposta a me ajudar. A todos os Professores e Médicos contratados do Departamento de Ginecologia e Obstetrícia da Faculdade de Medicina de Ribeirão Preto, em especial a Silvana Quintana, Patrícia Melli, Anderson Melo cuja oportunidade de convivência e aprendizados me tornaram uma profissional melhor. Aos Professores Doutores: Marcos Felipe Silva de Sá e Andréa Garcia, pela disponibilidade para participar da minha banca de doutorado fornecendo sugestões que contribuirão com meu aprendizado. A todos que direto ou indiretamente me ajudaram a concretizar em trabalho. RESUMO BRAGA, GC. Efeito do uso de anticoagulante oral sobre o padrão de sangramento associado ao uso do sistema intrauterino liberador de levonorgestrel em mulheres portadoras de trombofilia e/ou com passado de trombose. Dissertação (Mestrado)

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“…Logically, after entering the circulation, copper arrives at other organs, including the liver, kidneys, brain, and bones. Copper accumulation is progressive, thus large amounts of copper could be detected in these tissues; copper concentration in blood, on the other hand, is relatively less important, which may explain why no difference was reported in the urinary copper excretions [ 20 , 21 ]. Copper toxicity primarily affects the liver, which is the first deposition site once copper has entered the blood.…”

Section: Discussionmentioning

confidence: 99%

Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats

Zhao

Liu²,

Sun

et al. 2017

Med Sci Monit

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BackgroundThe aim of this study was to evaluate the chronic systemic and local toxicity of a copper intrauterine device in a rat model.Material/MethodsCu-IUD fragments were inserted into the uterine horns of female Wistar rats for 26 weeks (equivalent 15.42–17.33 years in humans). We tested copper at 20, 40, and 60 times the clinical dosages to study copper toxicity under severe conditions. Classic chronic systemic toxicity evaluations, including body weight, hematology, organ coefficient, and tissue reactions, were performed.ResultsThe body weight of the rats increased during the 26 weeks, which showed that the Cu-IUD implant had no effect on animal growth. Histological examinations and organ coefficients of the uterus and other major organs indicated no obvious systemic or local impairment. Blood tests confirmed that the hepatic and renal functions remained normal.ConclusionsThese results obtained at different dosages and long-term implantation provide solid data confirming the safety of long-term use of Cu-IUDs. However, the elevated leucocyte levels found in this study warrant further investigation.

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Hemoglobin and serum ferritin levels in women using copper-releasing or levonorgestrel-releasing intrauterine devices: a systematic review

Cited by 38 publications

References 37 publications

Prevalence and risk factors of anaemia among ever-married women in Jordan

Prevalence and risk factors of anaemia among ever-married women in Jordan

Efeito do uso de anticoagulante oral sobre o padrão de sangramento associado ao uso do sistema intrauterino liberador de levonorgestrel em mulheres portadoras de trombofilia e/ou com passado de trombose

Chronic Systemic Toxicity Study of Copper Intrauterine Devices in Female Wistar Rats

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