Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells

Standl, Thomas; Freitag, M.; Burmeister, Marc-Alexander; Horn, Ernst-Peter; Wilhelm, Stefan; Esch, Jochen Schulte am

doi:10.1067/mva.2003.127

Cited by 62 publications

(47 citation statements)

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“…8 Standl et al showed preservation of skeletal muscle oxygenation in dogs. 9 Thus the data from Freitag et al 1 are consistent with observations previously made in normovolemic anemia and extends our understanding by employing a larger animal (dog) and a different HBOC (Hemopure). A common observation in all of these studies is an increase in blood pressure and in systemic vascular resistance.…”

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confidence: 86%

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The utility of hemoglobin based oxygen carriers (HBOC) - can animal studies help?

Hall

2005

Can J Anesth/J Can Anesth

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confidence: 86%

“…ont montré la préser-vation de l'oxygénation des muscles squelettiques chez des chiens. 9 Les données de Freitag et coll. 1 correspondent donc aux observations faites précédemment pendant l'anémie normovolémique et elles ajoutent à nos connaissances en employant un animal plus gros, le chien, et une HBOC différente, l'Hemopure.…”

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The utility of hemoglobin based oxygen carriers (HBOC) - can animal studies help?

Hall

2005

Can J Anesth/J Can Anesth

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“…Moreover, the oxygen-dissociation curve for HBOC-201 was shifted to the right relative to human hemoglobin, meaning that HBOC-201 was more able to unbind oxygen in the periphery and release it to the target organs. Standl et al [22,23] compared HBOC with autologous blood as resuscitation for dogs after massive blood loss. They found that the increase in skeletal muscle tissue oxygen tension per gram of transfused hemoglobin was higher after HBOC transfusion than after autologous RBC transfusion.…”

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Hemoglobin substitutes

2004

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“…Hemodynamically, increases in mean arterial pressure (MAP) and systemic vascular resistance are seen after HBOC-201 administration (18), likely through nitric oxide (NO) inhibition (12,15). Oxygen delivery to tissue has been shown to be faster and three times more efficient than human Hb (20,26). These properties, along with a lower viscosity and smaller mean diameter than a human RBC, suggest that blood substitutes may be an effective therapy in acute myocardial ischemia.…”

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A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia

George¹,

Yi²,

Schulman³

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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. A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia. Am J Physiol Heart Circ Physiol 291: H1126 -H1137, 2006. First published April 14, 2006 doi:10.1152/ajpheart.00076.2006.-The purpose of this study was to test if HBOC-201, a hemoglobin-based oxygen-carrying solution, can decrease infarct size (or Inf) during acute, severe myocardial ischemia and reperfusion. To test the impact of HBOC-201 on infarct size, ischemia was produced in 18 dogs by coronary stenosis to achieve 80 -95% flow reduction for 195 min along with pacing 10% above the spontaneous heart rate, followed by 180 min of reperfusion. Animals were randomized to intravenous infusion of HBOC-201 (1 g/kg) (n ϭ 6), normal saline (NS) (n ϭ 6), or phenylephrine (Phe) (n ϭ 6, as a control for the increased blood pressure seen with HBOC-201), given 15 min after the start of ischemia. Amount of infarct was quantified as the ratio between area at risk (AAR) and Inf after Evans blue and 2,3,5-triphenyltetrazolium chloride staining. Hearts were divided into five layers from base (layer A) to apex (layer E) and photographed for digital image analysis of AAR and Inf. Regional myocardial function (RMF) was also measured after 60 min of ischemia and 15 min of reperfusion. Inf/AAR was significantly reduced after HBOC-201 therapy (4.4 Ϯ 2.2%) vs. NS (26.0 Ϯ 3.6%) and Phe (25.7 Ϯ 4.1%) (both, P Ͻ 0.05). RMF after reperfusion was restored to 92% of baseline with HBOC-201 compared with 11% of baseline after NS (P Ͻ 0.05) and 49% after Phe (P ϭ not significant). HBOC-201 administration after induction of severe myocardial ischemia by acute coronary stenosis reduces infarct size and improves myocardial viability.coronary; blood; nitric oxide inhibitor OVER 600,000 people die each year in the United States from complications of ischemic heart disease, including acute myocardial infarction (AMI), congestive heart failure (CHF), and fatal arrhythmias (22), and its treatment continues to challenge the medical community. With an estimated 1.1 million new cases of AMI each year, the burden on the health care system and society is enormous (2). The need for improved myocardial protection after acute ischemia is paramount. Despite a vast array of therapies that reportedly attenuate ischemiareperfusion injury, clinical application of these therapies has been meager and disappointing (22). The trend for earlier percutaneous revascularization (PCI) has helped to improve outcomes (11). However, the problems of contractile dysfunction during acute ischemia, expansion of infarct size (or Inf), and reperfusion injury have largely remained unaddressed and are more complex than simply restoring flow. In addition, the logistical requirements for early PCI, such as trained interventional cardiologists, specialized equipment, and transport time to treatment, limit its use as an immediate treatment for patients with AMI. Thus a noninvasive cardioprotective strategy that can be applied in a prehospital ...

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Hemoglobin-based oxygen carrier HBOC-201 provides higher and faster increase in oxygen tension in skeletal muscle of anemic dogs than do stored red blood cells

Abstract: Compared with RBC transfusion, infusion of low doses of HBOC-201 maintain enhanced oxygen extraction after extended hemodilution and provide faster and higher increase in muscular tissue PO(2).

Cited by 62 publications

References 27 publications

The utility of hemoglobin based oxygen carriers (HBOC) - can animal studies help?

The utility of hemoglobin based oxygen carriers (HBOC) - can animal studies help?

Hemoglobin substitutes

A polymerized bovine hemoglobin oxygen carrier preserves regional myocardial function and reduces infarct size after acute myocardial ischemia

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