Hemoglobin Carbamylation in Uremia

Glycosylated Hemoglobin and Mortality in Patients with Nondiabetic Chronic Kidney Disease

“…The main limitations are lack of follow-up HbA 1c measurements and the potential misclassification of cause of deaths; however, the latter should not influence the relationship between HbA 1c and all-cause mortality. In addition, it must be acknowledged that the use of the HPLC method to measure HbA 1c may result in overestimation of HbA 1c levels in uremia as a result of interference with carbamylated hemoglobin (39). However, it has been shown that carbamylated hemoglobin constitutes a small fraction of HbA 1c in dialysis patients (40).…”

Optimal glucose control in type 2 diabetes mellitus—a guide for the family practitioner

“…14,15 Take note that inaccurate HbA1c values occur in conditions with rapid red blood cell turnover, in patients with HIV and in renal failure. 16,17,18 OFFICE AND FASTING PLASMA GLUCOSE MEASUREMENTS Fasting plasma glucose correlates with HbA1c in type 2 diabetic patients, since the fluctuations in blood glucose are not as severe as in type 1 diabetic patients. It thus can give an indication of glycaemic control, but does not replace the HbA1c as a measure of blood glucose control.…”

Correction formula for carbamylated haemoglobin in diabetic uraemic patients

“…6 Carbamylated haemoglobin has been the major carbamylated protein studied, owing to initial studies that sought to use cyanate as a therapy for sickle-cell anaemia. 7 Fluckiger et al 8 were the ®rst to identify carbamylated haemoglobin in uraemic patients and correlated it to time-averaged urea concentration. Oimomi et al 9 then investigated the possibility of using carbamylated haemoglobin as an indicator of control in patients with renal failure.…”