Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro

Lithanatudom, Pathrapol; Wipasa, Jiraprapa; Inti, Pitsinee; Chawansuntati, Kriangkrai; Svasti, Saovaros; Fucharoen, Suthat; Kangwanpong, Daoroong; Kampuansai, Jatupol

doi:10.1371/journal.pone.0148079

Cited by 16 publications

(11 citation statements)

References 25 publications

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“…This finding suggests a protective role of HbE and was supported by other in vitro studies [24, 60]. On the other hand, another study compared seven HbAE patients with seven HbAA patients and found that the level of infected RBCs was not associated with the status of HbE carriers after a 96-hr incubation of RBCs and P. falciparum [61]. However, this sample size was much smaller than previous studies [21] such as the aforementioned study by Chotivanich et al which had samples of HbAA ( n = 34), HbAE ( n = 20) and HbEE ( n = 22).…”

Section: Studies On the Association Between Hbe And Malariasupporting

confidence: 62%

Hemoglobin E, malaria and natural selection

Martinson

Iwamoto

et al. 2019

Evolution, Medicine, and Public Health

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It is known that there has been positive natural selection for hemoglobin S and C in humans despite negative health effects, due to its role in malaria resistance. However, it is not well understood, if there has been natural selection for hemoglobin E (HbE), which is a common variant in Southeast Asia. Therefore, we reviewed previous studies and discussed the potential role of natural selection in the prevalence of HbE. Our review shows that in vitro studies, evolutionary genetics studies and epidemiologic studies largely support an involvement of natural selection in the evolution of HbE and a protective role of HbE against malaria infection. However, the evidence is inconsistent, provided from different regions, and insufficient to perform an aggregated analysis such as a meta-analysis. In addition, few candidate gene, genome-wide association or epistasis studies, which have been made possible with the use of big data in the post-genomic era, have investigated HbE. The biological pathways linking HbE and malaria infection have not yet been fully elucidated. Therefore, further research is necessary before it can be concluded that there was positive natural selection for HbE due to protection against malaria. Lay summary: Our review shows that evidence largely supports an involvement of natural selection in the evolution of HbE and a protective role of HbE against malaria. However, the evidence is not consistent. Further research is necessary before it is concluded.

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Section: Studies On the Association Between Hbe And Malariasupporting

confidence: 62%

Hemoglobin E, malaria and natural selection

Martinson

Iwamoto

et al. 2019

Evolution, Medicine, and Public Health

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“…1 ). Genomic DNA samples of MO6, Yuan, Lue, Khuen and Karen were from previous studies [ 12 , 13 ] while the MO7 and CT groups were newly-collected saliva samples obtained with written informed consent. DNA was extracted by QIAamp DNA Midi Kit (Qiagen, Germany).…”

Section: Methodsmentioning

confidence: 99%

New insights from Thailand into the maternal genetic history of Mainland Southeast Asia

et al. 2018

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Tai-Kadai (TK) is one of the major language families in Mainland Southeast Asia (MSEA), with a concentration in the area of Thailand and Laos. Our previous study of 1234 mtDNA genome sequences supported a demic diffusion scenario in the spread of TK languages from southern China to Laos as well as northern and northeastern Thailand. Here we add an additional 560 mtDNA genomes from 22 groups, with a focus on the TK-speaking central Thai people and the Sino-Tibetan speaking Karen. We find extensive diversity, including 62 haplogroups not reported previously from this region. Demic diffusion is still a preferable scenario for central Thais, emphasizing the expansion of TK people through MSEA, although there is also some support for gene flow between central Thai and native Austroasiatic speaking Mon and Khmer. We also tested competing models concerning the genetic relationships of groups from the major MSEA languages, and found support for an ancestral relationship of TK and Austronesian-speaking groups.

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“…Sample collection and DNA extraction for all new Thailand populations in this study apart from Akha was described in previous studies [23,[37][38][39][40][41]. Saliva samples were obtained from volunteers with signed informed consent from four Akha villages in the Chiang Rai province, Thailand.…”

Section: Samplingmentioning

confidence: 99%

Indian genetic heritage in Southeast Asian populations

Changmai

Jaisamut

Kampuansai

et al. 2021

Preprint

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The great ethnolinguistic diversity found today in mainland Southeast Asia (MSEA) reflects multiple migration waves of people in the past. Deeply divergent East Eurasian hunter-gatherers were the first anatomically modern human population known to migrate to the region. Agriculturalists from South China migrated to the region and admixed with the local hunter-gatherers during the Neolithic period. During the Bronze and Iron Ages, the genetic makeup of people in MSEA changed again, indicating an additional influx of populations from South China. Maritime trading between MSEA and India was established at the latest 300 BCE, and the formation of early states in Southeast Asia during the first millennium CE was strongly influenced by Indian culture, and this cultural influence is still prominent today. Several ancient Indian-influenced states were located in present-day Thailand, and various populations in the country are likely to be descendants of people from those states. To systematically explore Indian genetic heritage in MSEA, we generated genome-wide SNP data (the HumanOrigins array) for 119 present-day individuals belonging to 10 ethnic groups from Thailand and co-analyzed them with published data from MSEA using the PCA, ADMIXTURE, f3-statistics, qpAdm, and qpGraph methods. We found South Asian low-level admixture in various MSEA populations which are probably descendants of people from the ancient Indian-influenced states, but failed to find a South Asian genetic component in present-day hunter-gatherer groups and relatively isolated groups from highlands in Northern Thailand. Our results also support close genetic affinity between Kra-Dai-speaking (also known as Tai-Kadai) and Austronesian-speaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.Author SummaryMainland Southeast Asia is a region with great ethnolinguistic diversity and complex population history. We studied genetic population history of present-day mainland Southeast Asian populations using genome-wide SNP data (the HumanOrigins array). We generated new data for 10 present-day ethnic groups from Thailand, which we further combined with published data from mainland and island Southeast Asians and worldwide populations. We revealed South Asian genetic admixture in various mainland Southeast Asian ethnic groups which are highly influenced by Indian culture, but failed to find it in groups who remained culturally isolated until recently. Our finding suggests that a massive migration of Indian people in the past was responsible for the spread of Indian culture in mainland Southeast Asia. We also found support for a close genetic affinity between Kra-Dai- and Austronesianspeaking populations, which fits a linguistic hypothesis suggesting cladality of the two language families.

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Hemoglobin E Prevalence among Ethnic Groups Residing in Malaria-Endemic Areas of Northern Thailand and Its Lack of Association with Plasmodium falciparum Invasion In Vitro

Cited by 16 publications

References 25 publications

Hemoglobin E, malaria and natural selection

Hemoglobin E, malaria and natural selection

New insights from Thailand into the maternal genetic history of Mainland Southeast Asia

Indian genetic heritage in Southeast Asian populations

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