Hemoglobin G Waimanalo: α64 Asp → Asn

First Observation of Hemoglobin G-Waimanalo and Hemoglobin Fontainebleau Cases in the Turkish Population

“…When a point mutation is suspected, resequencing of the alpha genes has become a routine procedure [ 1 ]. Hb G-Waimanalo is a silent mutation characterized by a substitution to aspartic acid from asparagine at codon 64 [A64(A2), Asp>Asn] [ 2 ]. Hb Fontainebleau is a slightly unstable mutation characterized by a substitution to alanine from proline at codon 21 [A21(A2), Ala>Pro] [ 3 ].…”