Abstract:HMB had significant repercussions in the social, medical and economic aspects of women. The impact on the QoL was associated with the hematimetric parameters.
“…However, those women with VWD reported higher BS than the subjects in our study, which may explain these contradictory results. Menorrhagia has been shown to have a significant impact on HRQOL in women in general as well as in women with bleeding disorders . Menorrhagia was also one of the major bleeding symptoms in carriers in our cohort, as has been reported elsewhere .…”
We conclude that the subgroup of carriers of haemophilia with increased bleeding tendency have impaired HRQOL. The SF-36 results indicate that this condition affects mental rather than physical health.
“…However, those women with VWD reported higher BS than the subjects in our study, which may explain these contradictory results. Menorrhagia has been shown to have a significant impact on HRQOL in women in general as well as in women with bleeding disorders . Menorrhagia was also one of the major bleeding symptoms in carriers in our cohort, as has been reported elsewhere .…”
We conclude that the subgroup of carriers of haemophilia with increased bleeding tendency have impaired HRQOL. The SF-36 results indicate that this condition affects mental rather than physical health.
“…Our mean Hb levels were in agreement with others previous studies (6)(7)(8)(9). The serum ferritin levels showed variability in publications from other countries and they are lower than those found in our study (5,8).…”
“…One previous clinical trial of pharmacologic HMB treatment did report a high degree of correlation between MBL reduction and treatment satisfaction in women with HMB, but the MBL estimation was subjective rather than objective 12 . More recently, de Souza and colleagues found no correlation between MBL as measured by the Pictorial Blood Loss Assessment Chart and HRQL derived from the Short Form-36 (SF-36) questionnaire 13 . The SF-36 is a nonspecific HRQL measure that has been criticized for its lack of applicability in an HMB population, with some women reporting difficulty in answering SF-36 questions 9,14 .…”
Reducing measurable MBL by 36 mL/cycle, or approximately 22%, was considered to be a meaningful improvement for the majority of women with HMB in this study population.
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