Hemoglobin Variants in India

Ajmani, Manju; Sharma, Archana; Talukder, Geeta

doi:10.1017/s0001566000009466

Cited by 8 publications

(4 citation statements)

References 65 publications

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“…More re cently it has been shown that HbE is inef ficiently synthesized due to a reduction of |)E mRNA which produced a mild type of P-thalassemia [Traegeret al, 1980]. In contrast, not much was known about [Ajmani et al, 1978], Das et al [1971] and Flatz et al [1972], however, reported high frequencies of HbßE in certain populations of North east India having ethnic relationships with Southeast Asia. Subsequently, from this area other population groups of different ethnic origins were examined.…”

Section: Introductionmentioning

confidence: 99%

Hemoglobin E Distribution in Ten Endogamous Population Groups of Assam, India

et al. 1988

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Previous studies have reported a high incidence of hemoglobin E (HbE) in Northeast Indian populations. In the present study 10 endogamous populations of Assam belonging to two racial groups, Caucasoid and Mongoloid, were examined. The frequency of HbE gene (Hb βE) in the Caucasoid caste populations is around 0.1, whereas the gene is highly prevalent in the Mongoloid populations, frequencies ranging between 0.2 and 0.6. Predominance of Hb βE in the Tibeto-Burman speakers is contrary to observations made in Southeast Asia, where an association between Austro-Asiatic speakers and high prevalence of HbE exist. The highest occurrence of the gene in this area, which is on the far end of the proposed centre of distribution in Northern Kampuchea and Northeast Thailand, is also a deviation from the expected pattern of gene distribution. It is speculated that Hb βE in the Tibeto-Burman populations of Assam arose by an independent mutation which contributed to the high frequencies of Hb βE in the Northeast Indian populations.

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Section: Introductionmentioning

confidence: 99%

Hemoglobin E Distribution in Ten Endogamous Population Groups of Assam, India

et al. 1988

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“…They include HbD, which clusters in the populations of Northern India and Pakistan and reaching 2% in some populations (Ajami, et aI1978, Undevia, et aI1985). Haemoglobin B, J, K, Land Q have all been recorded at lower frequencies, again with evidence of local clustering (Ajami, et al 1978). The significance of these findings is unclear but they are intriguing as the distributions of these haemoglobinopathies suggest they may be malarial resistance traits.…”

Section: Other Haemoglobinopathiesmentioning

confidence: 94%

“…Sickle cell trait is present at lower frequency in the Hindu castes but is typically present at lower frequencies, typically less than 10% and is much lower in some groups, for example the Parsis in Bombay (less than 1 %). The ranges reported for the incidence of Hb S in different regions of India are therefore very variable within states for example Orissa (0-25%), Uttar Pradesh (0-18%), Madhya Pradesh (0-31%) Andra Pradesh (0-34%), Tamilnadu (0-31%), Kerela (0-26%), Karnataka (0-23%), Maharashtra (0-484 THE GENETICS OF MALARIA AND THE INDIAN SUBCONTINENT 33%), Gujarat (0-30%) and Rajasthan (0-18%) (Ajami, et al 1978, Mukherjee 2002, Roy andChaudhuri 1967).…”

Section: The Distribution Of Sickle Cell Traitmentioning

confidence: 99%

Genetic Disorders of the Indian Subcontinent

Kumar¹

2004

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“…Hb E has been reported in a compound heterozygous state with other variant hemoglobins like Hb C ( HBB Glu6Lys), Hb Malay ( HBB Asn19Ser), and Hb S. Hb S is prevalent in several parts of India, with frequencies reaching as high as 22% in Central India [1] . Hb E is common in the northeastern regions of the country, with frequencies of 4-50% [2,3] . Hemoglobin D-Punjab (Hb D) ( HBB Glu121Gln), an abnormal hemoglobin, is widespread in Northwestern India [4] .…”

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confidence: 99%