Hemoglobinopathies in Iran: An Updated Review

Nasiri, Abolfazl; Rahimi, Zohreh; Vaisi‐Raygani, Asad

doi:10.18502/ijhoscr.v14i2.2679

Cited by 16 publications

(12 citation statements)

References 89 publications

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“…However, participants in the Iranian Non-Jewish cluster had a significantly higher MAF for rs41464951 (cluster MAF: 0.0051, biobank MAF:8.79e-05, Fisher's exact test p-value: 5.02e-05), which has been found to be pathogenic for alpha thalassemia. This disease has been reported to be higher in Iranian and Middle Eastern populations [62], [63]. However, loci relating to GNE myopathy or alpha thalassemia are currently not regularly screened for in the UCLA Health System.…”

Section: Disease Allelesmentioning

confidence: 99%

Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobank

Caggiano

Boudaie

Shemirani

et al. 2022

Preprint

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An individual's disease risk is affected by the populations that they belong to, due to shared genetics and shared environment. The study of fine-scale populations in clinical care will be important for reducing health disparities and for developing personalized treatments. In this work, we developed a novel health monitoring system, which leverages biobank data and electronic medical records from over 40,000 UCLA patients. Using identity by descent (IBD), we analyzed one type of fine-scale population, an IBD cluster. In total, we identified 376 IBD clusters, including clusters characterized by the presence of many significantly understudied communities, such as Lebanese Christians, Iranian Jews, Armenians, and Gujaratis. Our analyses identified thousands of novel associations between IBD clusters and clinical diagnoses, physician offices, utilization of specific medical specialties, pathogenic allele frequencies, and changes in diagnosis frequency over time. To enhance the impact of the research and engage the broader community, we provide a web portal to query our results: www.ibd.la

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Section: Disease Allelesmentioning

confidence: 99%

Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobank

Caggiano

Boudaie

Shemirani

et al. 2022

Preprint

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“…Iranians are a multiethnic population, and the country lies in the so-called thalassemia belt of the world, where there is a high prevalence of hemoglobinopathies (such as thalassemia and sickle cell traits), which have ethnic predilections and can lead to increased unconjugated Bil levels. 5 Gilbert syndrome is also highly prevalent among Iranians, especially those with African ancestry, as occurs in melasma. 6 Moreover, the prevalence of hepatic, hematologic, or muscle disorders, as well as drug intake and cardiovascular diseases, is crucial to compare Bil between the groups.…”

Section: Concerning the Characterization Of Systemic Oxidative Stress...mentioning

confidence: 99%

Concerning the characterization of systemic oxidative stress in epidemiological studies of melasma: Comments on “Bilirubin as a new antioxidant in melasma”

Espósito¹,

D’Elia

Cassiano

et al. 2022

J of Cosmetic Dermatology

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“…β-Thalassemia is an inherited autosomal recessive disorder resulting from the decreased or the absence of βglobin chain synthesis. According to the clinical manifestations, β-thalassemia is categorized into β-thalassemia minor, β-thalassemia intermedia, and β-thalassemia major (5). In β-thalassemia major, regular blood transfusions can decrease anemia-related complications, compensate for bone marrow expansion, and improve the survival rate of patients.…”

Section: β-Thalassemia and Covid-19mentioning

confidence: 99%

Thalassemia and COVID-19: Susceptibility and Severity

et al. 2021

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Context: COVID-19 results in an imbalance between procoagulant and anticoagulant homeostatic mechanisms that could be complicated with thrombotic events. In β-thalassemia patients, the presence of comorbidities, iron overload, adrenal hypofunction, splenectomy, and chronic hypercoagulable state might increase the susceptibility to COVID-19 and its severity. Evidence Acquisition: The search was conducted in PubMed, Web of Science, and Scopus databases for the key terms of β-thalassemia/thalassemia and COVID-19 until July 2021. Results: The survey of published observational studies (mostly multicenter and case reports) indicated a lower prevalence of COVID-19 in β-thalassemia patients compared with the general population, as well as mild to moderate COVID-19 in these patients, especially in those without comorbidity. β-Thalassemia children were susceptible to COVID-19 but with less severity compared to adults. There is no report of pulmonary embolism and thrombotic events in β-thalassemia patients with COVID-19; however, coagulation abnormality and pulmonary microembolism have been found in these patients. Conclusions: Findings could be interpreted by the presence of high hemoglobin F (HbF) levels, the advantage of hydroxyurea (HU) therapy, splenectomy, and iron chelation therapy in these patients. However, due to the low sample size and studying mainly young patients, the results should be interpreted with caution, and it still needs more studies with a larger sample size to confirm these findings.

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Hemoglobinopathies in Iran: An Updated Review

Cited by 16 publications

References 89 publications

Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobank

Health care utilization of fine-scale identity by descent clusters in a Los Angeles biobank

Concerning the characterization of systemic oxidative stress in epidemiological studies of melasma: Comments on “Bilirubin as a new antioxidant in melasma”

Thalassemia and COVID-19: Susceptibility and Severity

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