Hemolymphomicrocirculatory bed of the pancreas during acute experimental pancreatitis

Abstract

Histochemical study of rat pancreas was carried out on days 14 and 30 of acute pancreatitis. The area of the stroma increased after damage and the area of lymph microcirculatory component increased in comparison with the blood circulation component.

Pathophysiology of the abdominal compartment syndrome in acute pancreatitis: Dilemmas and critical points

“…Apart from the aforementioned, the alteration of the pancreatic microcirculation plays one of the central roles in the pathogenesis of AP. Derangement of pancreatic microcirculation in the early phase of disease could transform acute self-limited and edematous pancreatitis to severe, necrotizing pancreatitis [24][25][26][27] . In response to pancreatic acinar cell injury, multiple proinflammatory cytokines and vasoactive mediators are recruited to the pancreatic microcirculation and delivered to the acinar cells.…”

Fluid Replacement Strategy in Severe Acute Pancreatitis

“…From a pathological point of view, alteration of the pancreatic microcirculation plays a central role in the pathogenesis of acute pancreatitis because a disruption of pancreatic microcirculation may be involved in the transformation from interstitial edematous pancreatitis to severe, necrotizing pancreatitis [2][3][4][5]. Alteration in the pancreatic microcirculation may be due to hypovolemia, increasing capillary permeability, and hypercoagulability causing microthrombi, among other things, and the generation of oxidative free radicals with subsequent capillary endothelial damage has also been implicated.…”