Hemolysis after Mitral Valve Repair

Abstract

Hemolysis is a potential complication of mitral valve repair. We report a case of hemolytic anemia after mitral valve repair successfully treated with re-repair, and review the literature on reoperation after failure of mitral valve repair with associated hemolysis.

Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress

“…Our finding that Hx prevents systolic dysfunction in an experimental model of intravascular hemolysis, such as in PHZ-treated mice, supports this view and conclusively proves a causative role for NHBH in left ventricular dysfunction associated to hemolytic disorders. Furthermore, Hx could be important in case of cardiac valve surgery, where mechanical forces and shear stress are significantly increased [51,52]. Consistently, hemolysis associated to high shear stress has been reported after mitral valve repair [51,52] and could contribute to heart failure in these patients.…”

“…Furthermore, Hx could be important in case of cardiac valve surgery, where mechanical forces and shear stress are significantly increased [51,52]. Consistently, hemolysis associated to high shear stress has been reported after mitral valve repair [51,52] and could contribute to heart failure in these patients.…”

Reoperation after mitral valve repair in viewpoints of kidney injury as well as hemolytic anemia

“…Of these, the reports we chose fulfilled the following three conditions: a clear degree of MR jet as seen on Doppler echocardiography; a clear interval from initial operation to the appearance of hemolysis, and a clear oneto-one relation between the MR grade and the interval in the case series; and an absence of causes other than MR jet collision, including partial annuloplasty dehiscence, protruding paravalvular suture material, the whiplash motion of tendinous chords, or regurgitant jet collision with the pledget or atrial wall. We evaluated nine case reports and two case series of hemolysis caused by unendothelialization of the annuloplasty ring with or without MR jet collision as measured by echocardiography or reoperation (Table 3) [4,[12][13][14][15][16][17][18][19][20][21]. The cases of reoperation include seven reports and two series.…”

Hemolytic Anemia with Fragmented Red Blood Cells Following Vascular Access Grafting for Hemodialysis in a Patient with Chronic Kidney Disease

“…They concluded that mechanical damage to RBC occurred because of blood flow disturbance, with the rapid acceleration and deceleration of the regurgitant jet, and high shear stress on the RBC [6]. Other authors have also reported the hemolytic anemia as the potential complication of mitral valve repair [7,8].…”