Hemolysis of Erythrocytes by Antibacterial Preservatives II

Nh125 Kills Methicillin-Resistant Staphylococcus Aureus Persisters by Lipid Bilayer Disruption

“…16-BAC is a benzalkonium chloride (BAC) analog, which is commonly used as a component of ophthalmic products, antiseptics, disinfectants and sanitizers [44]. However, it has been reported that BAC is cytotoxic and can cause lysis of human erythrocytes [51], corneal epithelial cells [52] and nasal epithelial cells [53]. Because NH125 disrupts GUVs relatively slowly compared with 16-BAC ( Figure 5 & Supplementary Video 1 & 2), we hypothesized that NH125 may be less cytotoxic than Research Article Kim, Fricke, Conery et al 16-BAC.…”

Construction of a quaternary ammonium salt platform with different alkyl groups for antibacterial and biosensor applications

“…Previous research has shown that quaternary ammonium salt monomers with various chain lengths can be synthesized and processed. In particular, Zhou et al 24 considered DM as a suitable biomaterial for performing direct electrochemistry of proteins because its characteristics [25][26][27] such as its biocompatibility, [28][29][30] high hydrophilicity, non-toxicity, and low cost. In addition, there are some reports in the literature in which DM can catalyze redox processes, creating a base for future electrochemical sensors.…”

Building a Better Quaternary Ammonium Compound (QAC): Branched Tetracationic Antiseptic Amphiphiles

“…Such ac omparison has been used for QACs for over half ac entury and is as tandard measure of therapeutic index. [23] Previous work in determining selectivity of antimicrobial activity over toxicity to eukaryotic cells has largely been focusedo na mphiphilic antimicrobial peptides (AMPs), biological analogues of QACs. [24][25][26] Such work has established that greater cationic nature tends to confers electivity for bacterial cell surfaces, as these tend to be more negatively charged than eukaryotic cells and are comprised of different components.…”