Hemolysis Which laboratory investigations and when?

Ja, Vilpo; Kk, Talvensaari; Mortensen, E. H.

doi:10.3109/00365519009090550

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…5 Clinically, the patient may appear jaundiced with a lack of splenomegaly, and the peripheral blood smear will reveal schistocytes, helmet cells, and fragmented red cells. 15 Acquired hemolytic anemia may develop from immune-or nonimmune-mediated factors. Drug-induced hemolytic anemia can occur as a result of one of the following mechanisms.…”

Section: Discussionmentioning

confidence: 99%

CASE REPORT: Cefazolin-induced Hemolytic Anemia

Cerynik¹,

Lee²,

Fayssoux³

et al. 2007

Clinical Orthopaedics &Amp; Related Research

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Antibiotic-induced hemolytic anemia is a rare complication. Prophylactic cephalosporins are widely used in patients having orthopaedic procedures. When there is a precipitous drop in hemoglobin levels, it is important for the clinician to consider the possibility of drug-induced anemia when other causes of blood loss have been excluded. We present a patient with no prior drug allergies who had antibiotic-induced hemolytic anemia develop after total knee arthroplasty.

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Section: Discussionmentioning

confidence: 99%

CASE REPORT: Cefazolin-induced Hemolytic Anemia

Cerynik¹,

Lee²,

Fayssoux³

et al. 2007

Clinical Orthopaedics &Amp; Related Research

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“…The highest values measured in megaloblastic anaemia were up to 29 times the upper reference limit. A free haemoglobin concentration in serum of 6-12 μηιοΐ/ΐ caused by disrupted erythrocytes, results in an increased lactate dehydrogenase activity of 10-20 U/l (55,56). Only 19 of their 32 patients had a pathological lactate dehydrogenase value.…”

Section: Anaemiamentioning

confidence: 99%

Review

1997

Clinical Chemistry and Laboratory Medicine

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The aim of this article is to describe guidelines for rational use of lactate dehydrogenase and its isoenzymes, in the diagnostic processes and during follow-up, based on a systematic review of relevant literature.Sources of data for this study were English-language scientific publications, obtained from the database of the National Library of Medicine (Medline), concerning the clinical application (diagnosis, monitoring or treatment of disease) of lactate dehydrogenase and lactate dehydrogenase isoenzyme measurements in serum in the following main clinical fields: cardiology, hepatology, haematology and oncology. For acceptance in the present review, studies had to include: a proper definition of the tested patient population, diagnostic criteria, sampling time, sampling frequency, and test characteristics.Estimation of the relation between lactate dehydrogenase or lactate dehydrogenase isoenzymes and specific diseases expressed as sensitivity, specificity, survival or remission rate were extracted.The application of serum lactate dehydrogenase is relevant in the diagnosis of myocardial infarction (late detection), haemolytic anaemia, ovarian dysgerminoma and testicular germ cell tumour. For monitoring the progress of a disease lactate dehydrogenase is relevant in establishing the survival duration and rate in Hodgkin's disease and non-Hodgkin's lymphoma, and in the follow-up of ovarian dysgerminoma. Rational use of lactate dehydrogenase can be achieved when requests for its determination are limited to the above mentioned conditions. No rationale could be found for measuring lactate dehydrogenase isoenzymes.( 3) screened the literature on erythrocyte sedimentation EC 2.7.3.2. rate, and their study resulted in guidelines for rational use. Enolase: ,, , " " ^ , . ,.. _f j ,.· phosphopyruvate hydratase, EC 4.2.1.11. Veldhuyzen van Zanten et al. (4) performed a prospective Mkaline phosphatase: study to test the clinical importance of routine measure-orthophosphoric-monoester phosphohydrolase, EC 3.1.3.1. Brought to you by |

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Blood Transfusion Reaction, Diagnosis, and Treatment

Leonard¹

1998

Blood Conservation in Cardiac Surgery

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Hemolysis Which laboratory investigations and when?

Cited by 3 publications

References 2 publications

CASE REPORT: Cefazolin-induced Hemolytic Anemia

CASE REPORT: Cefazolin-induced Hemolytic Anemia

Review

Blood Transfusion Reaction, Diagnosis, and Treatment

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