2012
DOI: 10.1097/pcc.0b013e31823c98ef
|View full text |Cite
|
Sign up to set email alerts
|

Hemolytic and thrombocytopathic characteristics of extracorporeal membrane oxygenation systems at simulated flow rate for neonates*

Abstract: Objective A state-of-the-art centrifugal pump combined with hollow-fiber oxygenator for extracorporeal membrane oxygenation has potential advantages such as smaller priming volumes and decreased potential to cause tubing rupture as compared with the traditional roller head/silicone membrane systems. Adoption of these state-of-the-art systems has been slow in neonates as a result of past evidence of severe hemolysis that may lead to renal failure and increased mortality. Extracorporeal systems have also been li… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
54
0

Year Published

2013
2013
2023
2023

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 51 publications
(56 citation statements)
references
References 37 publications
2
54
0
Order By: Relevance
“…Successful implementation of such a process within ECLS will open the door for similar efforts throughout critical care medicine. (30, 31)…”
Section: Discussionmentioning
confidence: 99%
“…Successful implementation of such a process within ECLS will open the door for similar efforts throughout critical care medicine. (30, 31)…”
Section: Discussionmentioning
confidence: 99%
“…Comorbid conditions were quantified with the Charlson Index [26]. While on ECMO, hepatic dysfunction was assessed by daily Liver SOFA scores [27, 28], and renal dysfunction was assessed either as acute kidney injury that was defined as 1.5 fold increase in creatinine [29], or the by the use of renal replacement therapy.…”
Section: Methodsmentioning
confidence: 99%
“…8,9 Previous work by this lab documented no difference in hemolysis or platelet aggregation in an in vitro neonatal ECMO model, using several different combinations of neonatal pumps and oxygenators. 10 Moreover, therapies directed toward the inhibition of shear-induced platelet activation have not changed the incidence of thrombus formation.…”
mentioning
confidence: 99%