Hemolytic Anemia in Viral Pneumonia With High Cold-Agglutinin Titer

Serum Factors of Acquired Hemolytic Anemia in Leukemia and Lymphoma*

“…It has been demonstrated experimentally in animals that specific immunization is accompanied not only by specific antibody formation but also by the appearance of gamma globulins nonreactive with the original challenge (43)(44)(45). A clinical counterpart of this experiment may perhaps be seen in some patients with primary atypical pneumonia and infectious mononucleosis who reveal certain serologic abnormalities such as rising heterophile titers and biologically false positive tests for syphilis and who also develop transient acquired hemolytic anemia (46)(47)(48)(49). Finally, to complicate this multi-faceted problem still further, the de novo synthesis of humoral antibody in patients with neoplastic disease is often impaired (50,51), and yet it is this type of patient who not infrequently develops acquired hemolytic anemia.…”

Symmetrical Peripheral Gangrene in Acquired Hemolytic Anemia

“…Lupus erythematosus (2, 12, 21) cells were not found on repeated examinations. There was no clinical or laboratory evidence of lymphoma (6), leukemia (6), cirrhosis of the liver (71), carcinomatosis (19,28) or atypical viral pneu monia (1). Serological tests for syphilis were negative.…”