Hemolytic Reactions Following Transfusions of Blood of the Homologous Group, with Three Cases in which the same Agglutinogen was Responsible

Wiener, Alexander S.; Peters, H. Raymond

doi:10.1007/978-94-011-6138-1_4

Cited by 65 publications

(11 citation statements)

References 22 publications

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“…11 Weiner and Peters opined that the transfusion of Rh positive blood to Rh negative individuals could result in development of anti-Rh agglutinins. 12 This was a research conducted in the Dept. of Transfusion Medicine and Neonatology division in the Dept.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Vilambil¹,

Dharmadas²,

Usha³

et al. 2017

jemds

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BACKGROUNDHaemolytic disease of foetus and newborn (HDFN) is triggered by enhanced destruction of red blood cell due to immune-mediated destruction, intrinsic abnormalities, acquired aberrations, etc. Lifespan of infant's erythrocytes are shortened by the action of placentally transferred maternal antibodies in immune-mediated HDFN.The aim of this study was to identify the frequency of maternal antibodies in neonates with hyperbilirubinaemia. Settings and Design-This was a cross-sectional study in neonates admitted to neonatal intensive care unit (NICU). Setting for the research was Dept. of Transfusion Medicine and Neonatology division of Sree Avittom Thirunal Hospital for women and children attached to Govt. Medical College, Trivandrum.

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Section: Discussionmentioning

confidence: 99%

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Vilambil¹,

Dharmadas²,

Usha³

et al. 2017

jemds

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“…3 Ensuing studies confirmed that the presence or absence of Rh factor directly correlated with the majority of ABO(H)-compatible transfusion reactions. 4 Subsequent reports demonstrated that the development of anti-Rh (RhD) antibodies might not only be responsible for ABO(H)-independent transfusion reactions, but may similarly underlie the development of hemolytic disease of the fetus and newborn (HDFN). 9 For .20 years, these studies exemplified the power of a multidisciplinary approach when seeking to not only understand but also develop a strategy to prevent a devastating disease.…”

Section: Working Together To Block Alloimmunization -----------------mentioning

confidence: 99%

Working together to block alloimmunization

Stowell

2016

Blood

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“…The study with 60 families showed that the positive Rh was inherited with dominant character. Also in 1940, Wiener et al 5 observed the same specificity in the serum of people who lacked the same determinant and who had received compatible ABO transfusions in the past.…”

mentioning

confidence: 93%

Bases moleculares do sistema Rh e suas aplicações em obstetrícia e medicina transfusional

Nardozza¹,

Szulman²,

Barreto³

et al. 2010

Rev. Assoc. Med. Bras.

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The Rh system is the most polymorphic and immunogenic of all blood group systems. Currently, over 49 antigens have been identified, among which the five main antigens are D, C, c, E, e. Knowledge of the Rh system's molecular basis, since its first cloning 17 years ago, has allowed for an understanding of the mechanism of Rh-negative phenotype and of the variants of antigens RHD and RHCE. Deletions, gene rearrangements and insertions are the main mutations. In Caucasians, the primary mechanism of Rh-negative phenotype is the complete RHD gene deletion, whereas in Afrodescendant it is the presence of pseudogene RHDø and hybrid gene RHD-CE (4-7)-D. The authors analyzed the structure of the Rh complex in red cells, the molecular basis of the Rh system, mechanisms of RHD negativity and weak and partial RHD expressions.

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Hemolytic Reactions Following Transfusions of Blood of the Homologous Group, with Three Cases in which the same Agglutinogen was Responsible

Cited by 65 publications

References 22 publications

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Working together to block alloimmunization

Bases moleculares do sistema Rh e suas aplicações em obstetrícia e medicina transfusional

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