Hemolytic-Uremic Syndrome

Corrigan, James J.; Boineau, Frank G.

doi:10.1542/pir.22-11-365

Cited by 68 publications

(54 citation statements)

References 7 publications

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“…About 8-30% patients went on to develop endstage renal disease (ESRD), and renal transplantation has been performed in three children in the literature [2,8,16]. In our study, six of seven patients received dialysis, and none of them developed ESRD at follow-up.…”

Section: Discussionmentioning

confidence: 66%

“…This disorder tends to occur in healthy young children and is one of the most common causes of acute renal failure in pediatric patients [19]. Most cases of HUS are preceded by an acute gastroenteritis related to Escherichia coli (O157:H7) and often have good prognosis with recovery of renal function [8]. However, Streptococcus pneumoniae (S. pneumoniae) has been associated with HUS and carries a higher risk of mortality and morbidity [2].…”

Section: Introductionmentioning

confidence: 99%

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Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan

et al. 2006

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Streptococcus pneumoniae ( S. pneumoniae ) has been associated with hemolytic uremic syndrome (HUS), which is an unusual but serious disease in childhood. We conducted a retrospective review of children aged less than 18 years with S. pneumoniae -associated HUS in northern Taiwan from January 2000 to June 2005. The demographic characters, clinical courses, and outcomes were analyzed. Seven children (three girls, four boys) with S. pneumoniae -associated HUS were studied. The median age at onset of HUS was 40 months (range: 25-60 months). The median duration of hospital stay was 36 days (range: 15-50 days). The interval between the onset of illness attributable to S. pneumoniae and the development of HUS was around 1-2 weeks. The onset of oliguria developed within 2 weeks after illness. Six patients required dialysis with median duration of 16 days. Three patients had leukopenia as the initial presentation. All seven patients had pneumococcal pneumonia complicating with empyema, and two of them received decortication via video-assisted thoracoscopic surgery. Between patients who needed dialysis or not, there was no significant difference in age, sex, duration of thrombocytopenia, incidence of extra-renal complications, such as hepatitis, pancreatitis, and hypertension, and length of hospital stay. The seven patients survived with normal renal function. HUS is a potentially fatal complication of S. pneumoniae infection. Clinicians managing patients with pneumococcal pneumonia with empyema accompanied by leukopenia should beware of the development of HUS. The long-term prognosis for recovery of renal function appears to be good in these patients in northern Taiwan.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan

et al. 2006

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“…Most cases are preceded by an episode of infectious, sometimes bloody, diarrhea caused by E. coli , which is acquired as a foodborne illness or from a contaminated water supply. It is a medical emergency and carries a 5%-10% mortality rate; of the remainder, the majority recovers without major consequences (9). In our case, petechiae, ecchymosis, and fragmented red blood cells were not found in her physical examination, and the laboratory results, LDH (lactate dehydrogenase), and bilirubin were in normal intervals.…”

Section: Discussionmentioning

confidence: 55%

A Rare Intraabdominal Infection; Renal Abcess

Eren¹,

Aktaş²,

Dusmez³

et al. 2014

JAEMCR

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Introduction: Renal abscess is an uncommon intraabdominal infection. It can cause significant morbidity and mortality. Diabetes mellitus (DM), urinary tract abnormalities, chronic debilitating disease, and intravenous drug abuse are the predisposing factors.Case Report: In this case report, we present a 30-year-old immunocompetent woman who presented with fever, dysuria, pollakiuria, right flank pain, nausea, and vomiting. She was first diagnosed as pyelonephritis. But, further investigations were made, and a renal abscess was found.Conclusion: Special attention should be given to patients with urinary tract infections having fever and ongoing symptoms despite antimicrobial treatment. ÖZETGiriş: Renal apse nadir görülen bir intraabdominal enfeksiyondur. Belirgin morbidite ve mortaliteye neden olabilir. Diabetes Mellitüs, üriner sisteme ait anormalilikler, kronik hastalıklar ve intravenöz ilaç kullanımı predispozan faktörlerdir.Olgu Sunumu: Biz bu vakada 30 yaşlında yüksek ateş, dizüri, pollakiüri, sağ yan ağrısı, bulantı ve kusma ile başvuran bir hastayı sunmaktayız. Hastada ilk once pyeleonefrit teşhisi konulmuş ancak ileri tetkikler sonucunda renal abse tespit edilmiştir Sonuç: Antimikrobiyal tedaviye rağmen semptomları devam eden ve ateşi olan ürüner sistem enfeksiyonlu hastalara daha fazla dikkat edilmelidir.

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“…Shiga toxin-producing E. coli (STEC) O157:H7 in humans was first reported in 1983 [3–5]. STEC causes a variety of diarrheal diseases and hemolytic uremic syndrome (HUS) [6]. EHEC belongs to the STEC group but it is associated with a distinctive clinical syndrome, namely hemorrhagic colitis (HC), mainly caused by E. coli O157:H7 [7, 8].…”

Section: Introductionmentioning

confidence: 99%

Whole-genome sequencing and comparative genomic analysis of Escherichia coli O91 strains isolated from symptomatic and asymptomatic human carriers

et al. 2016

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BackgroundThe Shiga toxin–producing Escherichia coli (STEC) O91:H21 strains NCCP15736 and NCCP15737 were isolated during a single outbreak in Korea, NCCP15736 from a symptomatic carrier and NCCP15737 from an asymptomatic carrier. To investigate genomic differences between the two strains, we performed whole-genome sequencing of both strains and conducted a comparative genomic analysis.ResultsUsing the Illumina HiSeq 2000 platform and Rapid Annotation using the Subsystem Technology (RAST) server, whole-genome sequences of NCCP15736 and NCCP15737 were obtained and annotated. Phylogenetic analysis of ten E. coli strains showed that NCCP15736 and NCCP15737 are evolutionarily close. The two strains were found to be most close to E. coli O91:NM str. 2009C-3745. The genomic comparison showed that the fimD gene of NCCP15737 is truncated and that the truncation could underlie the defects in infection and pathogenicity of NCCP15737. The two strains showed the same virulence factor profiles, and we identified 25 virulence factors from NCCP15736 and NCCP15737, respectively. We identified ten and nine phage-associated regions in the NCCP15736 and NCCP15737 genomes, respectively; the two strains share five of these.ConclusionsNCCP15736 and NCCP15737 differ at the genomic level, even though they share features such as virulence-related genes. NCCP15737 has a deletion in fimD, which may underlie its asymptomatic character. We conclude that complete genome sequencing and integration of other types of omics data are needed to fully reveal the mechanism underlying the asymptomatic character of NCCP15737.Electronic supplementary materialThe online version of this article (doi:10.1186/s13099-016-0138-9) contains supplementary material, which is available to authorized users.

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Hemolytic-Uremic Syndrome

Cited by 68 publications

References 7 publications

Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan

Hemolytic uremic syndrome associated with pneumococcal pneumonia in Taiwan

A Rare Intraabdominal Infection; Renal Abcess

Whole-genome sequencing and comparative genomic analysis of Escherichia coli O91 strains isolated from symptomatic and asymptomatic human carriers

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