Hemolytic uremic syndrome caused by E. coli O157 infection

Bystrom, Philip V.; Beck, Robert J.; Prahlow, Joseph A.

doi:10.1007/s12024-017-9852-y

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…52 The organism resides in the intestinal tract of live animals and is shed in their faeces, which may contaminate food, water, and the environment. [52][53][54][55] It has unusual persistence features in the environment and survives at low temperatures and under acidic conditions. 52,55 The infective dose of E. coli O157:H7 is very small (10-100 cells) and is implicated in severe clinical conditions including, haemorrhagic colitis leading to bloody diarrhoea, haemolytic uremic syndrome and kidney damage.…”

Section: Cockroaches and Food-borne Pathogensmentioning

confidence: 99%

“…52,55 The infective dose of E. coli O157:H7 is very small (10-100 cells) and is implicated in severe clinical conditions including, haemorrhagic colitis leading to bloody diarrhoea, haemolytic uremic syndrome and kidney damage. [52][53][54][55] S. aureus and B. cereus, also isolated from cockroaches, are among the predominant foodborne pathogens globally. Both pathogens have an infective dose of 10 5 to 10 6 cells and produce toxins, which mediate the food-borne disease; S. aureus produces enteroxins, which cause diarrhoea, 56 while B. cereus produces an emetic and enterotoxin responsible for vomiting and diarrhoea, respectively.…”

Section: Cockroaches and Food-borne Pathogensmentioning

confidence: 99%

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Cockroaches and Food-borne Pathogens

Donkor

2020

Environ�Health�Insights

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Food-borne disease is a widespread and escalating public health problem globally. About a quarter of the microorganisms isolated from cockroaches are food-borne pathogens including Escherichia coli O157:H7, Staphylococcus aureus, Bacillus cereus, Shigella dysenteriae, Salmonella enterica subsp. enterica serovar Typhi, Rotavirus, Aspergillus fumigatus, and Cryptosporidium parvum. Thus, cockroaches could be an important reservoir and mechanical vector of food-borne pathogens. Generally, the role of cockroaches in human infections is poorly understood and has been an issue of debate for several years. This article aims to elucidate the possible role of cockroaches in food-borne infections by reviewing the relevant research publications.

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Section: Cockroaches and Food-borne Pathogensmentioning

confidence: 99%

Section: Cockroaches and Food-borne Pathogensmentioning

confidence: 99%

Cockroaches and Food-borne Pathogens

Donkor

2020

Environ�Health�Insights

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Triazine-based covalent–organic framework embedded with cuprous oxide as the bioplatform for photoelectrochemical aptasensing Escherichia coli

Huo,

Shahab,

Dang

et al. 2023

Microchim Acta

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Enterohemorrhagic Escherichia coli

Fatima¹,

Aziz

2007

Food Microbiology: Fundamentals and Frontiers, Third Edition

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Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is responsible for causing outbreaks of bloody diarrhea and hemolytic-uremic syndrome throughout the world. The locus of enterocyte effacement (LEE) consists of five major operons and is required for the formation of attaching and effacing lesions that disrupt intestinal epithelial microvilli. We have previously reported that expression of EHEC LEE genes is regulated by the luxS quorum-sensing system. The luxS gene in EHEC affects the production of autoinducer 3 (AI-3), which activates the LEE. Epinephrine and norepinephrine also activate the LEE in a manner similar to that of AI-3. Previous studies of quorum-sensing regulation of LEE transcription have thus far been restricted to using reporter systems in an E. coli K-12 background. Here, we examined the kinetics of LEE gene transcription, protein expression, and function of the LEE type III secretion apparatus in wild-type (WT) EHEC and an isogenic luxS mutant. The results revealed that the luxS mutant had diminished transcription from the LEE promoters during the mid-exponential growth phase; decreased protein levels of EscJ, Tir, and EspA; and reduced secretion of EspA and EspB. The luxS mutation also caused a delay in the formation of attaching and effacing lesions on cultured epithelial cells compared to the wild type. Epinephrine enhanced LEE expression in both the WT and the luxS mutant, but the WT still exhibited greater LEE activation. The results suggest a possible synergistic relationship between AI-3 and epinephrine. The combined effects of these two signaling molecules may lead to greater LEE expression and a more efficient infection.

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Hemolytic uremic syndrome caused by E. coli O157 infection

Cited by 3 publications

References 12 publications

Cockroaches and Food-borne Pathogens

Cockroaches and Food-borne Pathogens

Triazine-based covalent–organic framework embedded with cuprous oxide as the bioplatform for photoelectrochemical aptasensing Escherichia coli

Enterohemorrhagic Escherichia coli

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