Hemolytic Uremic Syndrome in Pediatric Intensive Care Units in São Paulo, Brazil

Souza, Renato Lopes de; Carvalhaes, João Tomás de Abreu; Nishimura, Lucilia S.; Andrade, Maria Cristina de; Guth, Beatriz Ernestina Cabílio

doi:10.2174/1874285801105010076

Cited by 22 publications

(29 citation statements)

References 35 publications

(39 reference statements)

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“…However, almost half of these patients (46%) were less than 2 years old. These results show a higher risk for pediatric patients, also common victims of foodborne illnesses (Souza et al, 2011).…”

Section: Introductionmentioning

confidence: 73%

Molecular screening of bovine raw milk for the presence of Shiga toxin-producing Escherichia coli (STEC) on dairy farms

Vendramin¹,

Kich²,

Molina³

et al. 2014

Food Sci. Technol (Campinas)

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Section: Introductionmentioning

confidence: 73%

Molecular screening of bovine raw milk for the presence of Shiga toxin-producing Escherichia coli (STEC) on dairy farms

Vendramin¹,

Kich²,

Molina³

et al. 2014

Food Sci. Technol (Campinas)

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“…This may be due to excessive exposure to known risk factors associated with STEC infections, including meat consumption, playing in recreational water, and poor personal hygiene (198). In contrast, neighboring Brazil has low incidences of HUS (199), and cases of STEC O157:H7 are uncommon (200). While STEC infections are identified in other developing countries (201,202), overall surveillance and clinical diagnostics are lacking.…”

Section: Epidemiologymentioning

confidence: 99%

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

et al. 2013

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SUMMARY Although Escherichia coli can be an innocuous resident of the gastrointestinal tract, it also has the pathogenic capacity to cause significant diarrheal and extraintestinal diseases. Pathogenic variants of E. coli (pathovars or pathotypes) cause much morbidity and mortality worldwide. Consequently, pathogenic E. coli is widely studied in humans, animals, food, and the environment. While there are many common features that these pathotypes employ to colonize the intestinal mucosa and cause disease, the course, onset, and complications vary significantly. Outbreaks are common in developed and developing countries, and they sometimes have fatal consequences. Many of these pathotypes are a major public health concern as they have low infectious doses and are transmitted through ubiquitous mediums, including food and water. The seriousness of pathogenic E. coli is exemplified by dedicated national and international surveillance programs that monitor and track outbreaks; unfortunately, this surveillance is often lacking in developing countries. While not all pathotypes carry the same public health profile, they all carry an enormous potential to cause disease and continue to present challenges to human health. This comprehensive review highlights recent advances in our understanding of the intestinal pathotypes of E. coli .

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“…In Brazil, there is no systematic surveillance system for infection with STEC D157:H7 and HUS cases. However, research conducted in Brazil has demonstrated the occurrence of important STEC serotypes in human diseases, such as bloody diarrhoea, haemolytic anaemia and HUS (Guth et al, 2002;Souza et al, 2011). STEC D157:H7 naturally colonises the gastrointestinal tract and recto-anal junction of cattle, which are the main reservoir of STEC, and these animals are generally asymptomatic (Lim et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Survival of Shiga toxin-producing Escherichia coli O157:H7 in Minas frescal cheese

Frozi¹,

Domingues²,

Esper³

et al. 2015

Food Sci. Technol (Campinas)

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Shiga toxin-producing Escherichia coli (STEC) D157:H7 strains (isolated by cattle's faeces and a reference strain, EDL933), were inoculated into pasteurized milk (10 2 and 10 3 cells.mL -1) to prepare the Minas frescal cheese. As control was used uninfected milk. Physicochemical and microbiological analyses were performed to milk and elaborated cheese. The D157:H7 strains were quantified in the stages of cheese processing and during 0, 2, 4, 5, 7, 10 and 15 storage days at 8 °C onto Sorbitol MacConkey Agar supplemented with potassium tellurite and cefixime (CT-SMAC). D157:H7 was not present in the pasteurised milk prior to the artificial inoculation. At the end of the processing the cheese had 10 to 100 times more STEC D157:H7 than the initial inoculum. During the storage, the Minas frescal cheese exhibited the largest population increase on the 4th and 5th day when inoculated with 10 2 and 10 3 cells.mL -1, respectively. Additionally, viable cells were found up to the 10th and 15th day, according to the amount of initial inoculum. This number of cells is able to cause infection in humans, and therefore, Minas frescal cheese, even when stored under refrigeration, is a potential vehicle of disease caused by STEC D157:H7.Keywords: cheese; psychrotrophic bacteria; foodborne disease. Practical Application:This study demonstrates that the Minas frescal cheese may be an important vehicle for STEC D157:H7, since this microorganism remains viable in this food for a long period even under refrigeration. In this study we can observe the psychrotrophic behavior of STEC D157:H7 in this rich food which is Minas frescal cheese.

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Hemolytic Uremic Syndrome in Pediatric Intensive Care Units in São Paulo, Brazil

Cited by 22 publications

References 35 publications

Molecular screening of bovine raw milk for the presence of Shiga toxin-producing Escherichia coli (STEC) on dairy farms

Molecular screening of bovine raw milk for the presence of Shiga toxin-producing Escherichia coli (STEC) on dairy farms

Recent Advances in Understanding Enteric Pathogenic Escherichia coli

Survival of Shiga toxin-producing Escherichia coli O157:H7 in Minas frescal cheese

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