Hemophagocytic syndrome and COVID-19

Hemophagocytosis in bone marrow aspirates in multisystem inflammatory syndrome in children

“…Hemophagocytosis has been reported for adults in association with severe COVID-19 disease; however, there are no reported data for children with hemophagocytosis demonstrated by bone marrow aspiration. 10 These cases highlight that hemophagocytosis may be present on bone marrow aspirates in patients with MIS-C.…”

Recovery does not always signal the end of the battle: A case of post SARS-CoV-2 multisystem inflammatory syndrome in an adult

“…Secondary hemophagocytic lymphohistiocytosis (sHLH) is shown to be associated with severe SARS-CoV-2 infection and can present with immune system activation rapidly progressing to multi-organ failure [ 12 , 13 ]. Cardinal features of sHLH include unremitting fever, cytopenias, and hyperferritinaemia, pulmonary involvement including acute respiratory distress syndrome (ARDS) seen in approximately 50% of patients [ 14 ].…”

Complicated case of COVID-19 disease with overlapping features of thrombotic thrombocytopenic purpura and haemophagocytic lymphohistiocytosis

“…Haemophagocytic lymphohistiocytosis (HLH) is a rare phenomenon and occurs due to cytokine storms. 3 Thrombotic thrombocytopenic purpura (TTP), a classical type of microangiopathic haemolytic anaemia, is a very rare entity reported in the COVID-19 disease. 4 We report the first case of a complicated COVID-19 disease that had features of both HLH and TTP.…”