Hemophagocytic syndrome in the critically ill

Bouffandeau, B; Mofredj, Ali; Blanc, Serge

doi:10.1007/s001340100925

Cited by 10 publications

(5 citation statements)

References 3 publications

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“…Other viruses such as the herpes group viruses, cytomegalovirus, varicella zoster virus, human herpes virus 6-8, can also cause HS. 5,6 In addition to viral factors, bacterial, protozoal, fungal, parasitic diseases, malignancies, radical stress, metabolic diseases, immune deficiency, and collagen tissue disease may also lead to HS. 1 The clinical manifestations of HS occur with phagocytosis of leukocytes, erythrocytes, and platelets as a result of monocyte, macrophage, and histiocyte activation, and proliferation in tissues such as bone marrow, liver, spleen, lymph node, and skin.…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

A Rare Retrograde Intrarenal Surgery Complication: Hemophagocytic Syndrome

Akgül

Yazıcı

Ateş

et al. 2020

Journal of Endourology Case Reports

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Background: Hemophagocytic syndrome (HS) is a syndromic complex that is categorized in the group of histiocytic disorders associated with macrophages. Case Presentation: A 39-year-old male patient was admitted to the outpatient clinic with complaint of left flank pain. A 1 cm kidney stone was found in the upper pole of left kidney at radiologic imaging. The patient underwent retrograde intrarenal surgery (RIRS) with no peroperative complication. High fever and increasing of acute-phase reactants were observed at postoperative first day. Besides resistant fever, pancytopenia developed despite the appropriate antibiotherapy. The urine and blood cultures were sterile. After multidisciplinary consultation, bone marrow sampling was performed. Microscopic examination of the bone marrow material revealed that the macrophage cells phagocyted the erythrocytes, which was compatible with HS. Unfortunately despite the appropriate medical HS treatment, the patient died due to multiorgan failure at the 21st day of RIRS. Conclusion: HS is a significantly rare complication after RIRS, which was presented initially with postoperative fever. HS should be kept in mind if the patient had resistant fever and pancytopenia despite the appropriate antibiotherapy.

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Section: Discussion and Literature Reviewmentioning

confidence: 99%

A Rare Retrograde Intrarenal Surgery Complication: Hemophagocytic Syndrome

Akgül

Yazıcı

Ateş

et al. 2020

Journal of Endourology Case Reports

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“…2 It has subsequently been described as a response to infection, collagen-vascular disorders and malignancies; HLH as a secondary phenomenon is known as reactive haemophagocytic syndrome 3 and carries a high mortality. [4][5][6][7] The proposed diagnostic criteria of reactive HLH consist are outlined in Table 1 8 We describe a case of haemophagocytic syndrome in a patient with HIV-associated histoplasmosis. There have previously been 18 cases of histoplasmosis associated haemophagocytic syndrome reported, of which 12 have occurred in HIV positive patients.…”

Section: Discussionmentioning

confidence: 99%

A case of haemophagocytic syndrome in HIV-associated disseminated histoplasmosis

Vaid

Patel²

2011

Acute Med

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Disseminated histoplasmosis is an opportunistic infection which is commonly associated with HIV. Haemophagocytic lymphohistiocytosis (HLH) has been described as a secondary phenomenon to infection, collagen – vascular disorders and malignancies. In patients with HIV, cases of reactive haemophagocytic syndrome associated with disseminated histoplasmosis have been reported with CD4 counts of less than 50 cells/μl (450-1660 cells/μl). We report a case of a 25 year old man with HIV who presented with a CD4 count of 153 cells/μl and would suggest that this diagnosis should be considered at higher CD4 counts than previously reported.

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“…In HPS, treatment for the underlying disease is fundamental but not usually sufficient. The management of this cytokine storm is based not only on high‐dose steroids, but also on plasma exchange and chemotherapy (9).…”

Section: Discussionmentioning

confidence: 99%

Effect of Plasma Exchange on the Circulating IL‐6 Levels in a Patient With Fatal Hemophagocytic Syndrome Associated With Bile Ductopenia

Song

Sung

2006

Ther Apher Dial

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We report here the case of a patient suffering from hemophagocytic syndrome (HPS) associated with bile ductopenia. A 24-year old man was admitted after suffering fever, sore throat and general malaise for 7 days and jaundice for 2 days. Clinical studies showed hepatic dysfunction with hyperbilirubinemia. Epstein-Barr viral DNA from two bone marrow samples was detected. Bone marrow aspiration disclosed findings of HPS. Liver biopsy showed centrilobular cholestasis with lack of interlobular bile duct. Repeated therapeutic plasma exchange was effective for decreasing serum bilirubin and interleukin-6 levels. The patient received liver transplantation, however, he finally died of alveolar hemorrhage resulting from disseminated intravascular coagulation and acute rejection.

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Hemophagocytic syndrome in the critically ill

Cited by 10 publications

References 3 publications

A Rare Retrograde Intrarenal Surgery Complication: Hemophagocytic Syndrome

A Rare Retrograde Intrarenal Surgery Complication: Hemophagocytic Syndrome

A case of haemophagocytic syndrome in HIV-associated disseminated histoplasmosis

Effect of Plasma Exchange on the Circulating IL‐6 Levels in a Patient With Fatal Hemophagocytic Syndrome Associated With Bile Ductopenia

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