Hemophagocytosis and pulmonary involvement in brucellosis

Heydari, Ali Akbar; Ahmadi, Fereidoun; Sarvghad, Mohammad Reza; Safari, Hosein; Bajouri, Amir; Saeidpour, Mehdi

doi:10.1016/j.ijid.2006.01.003

Cited by 8 publications

(4 citation statements)

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“…Nevertheless, some reports have described the association with human immunodeficiency virus (HIV), adenovirus, coxsackie virus, measles, dengue, rubella, parvovirus B19, herpes simplex virus and varicella zoster virus 39 . Moreover, some cases of hemophagocytic syndrome have been reported in bacterial and protozoan infections 16,21 .…”

Section: Introductionmentioning

confidence: 99%

Hemophagocytic syndrome associated with hepatitis A: case report and literature review

Tuon

Gomes

Amato

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYVirus-Associated Hemophagocytic Syndrome (VAHS) is a severe hematological disorder related to some viral infections. It is an illness characterized by persistent fever, pancytopenia, splenomegaly, hyperferritinemia and, the most important, hemophagocytosis observed in the bone marrow, liver and/or lymph nodes. VAHS associated with hepatitis A virus infection is rarely described, despite the high incidence of this viral infection in the population in general. There is no consensus in the literature regarding the optimal treatment of VAHS. In this article the clinical features, presumed pathogenesis, diagnostic criteria and treatment of VAHS are discussed, including description of cases of VAHS related to hepatitis A virus infection found in the medical literature.

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Section: Introductionmentioning

confidence: 99%

Hemophagocytic syndrome associated with hepatitis A: case report and literature review

Tuon

Gomes

Amato

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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“…Thrombocytopenia occurs less than leukopenia in brucellosis. We and others have several published [8][9][10] and unpublished papers regarding confirmed brucellosis cases presenting with severe hemorrhagic fever mimicking Crimean-Congo Hemorrhagic Fever (CCHF). These patients are usually isolated before an established diagnosis is reached.…”

Section: Introductionmentioning

confidence: 99%

Brucella-induced Thrombocytopenia and Bleeding

Heydari¹

2015

Updates on Brucellosis

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Mild anemia and leukopenia are the most common hematologic problems of acute brucellosis. Mild thrombocytopenia also occurs, but severe cases are uncommon. Thrombocytopenia occurs because of bone marrow suppression, hypersplenisem, hemophagocytosis, and immunologic destruction of the cells or disseminated intravascular coagulation. In endemic areas, hemorrhagic fevers, hematologic malignancies, as well as idiopathic thrombocytopenic purpura should be considered as differential diagnoses for complicated brucellosis. Thrombocytopenia and bleeding can be improved with antibiotic and hematologic supportive therapy whereas in severe cases corticosteroid therapy or splenectomy might be necessary.

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“…Despite the treatable and nonfatal nature of brucellosis, it may involve nearly all body system, and the disease may present with complications such as thrombocytopenia. This complication can be severe with purpura and bleeding [2]. According to several studies [2][3][4], brucellosis may present with severe hemorrhagic fever similar to CCHF, which requires isolation of the patients before definitive diagnosis.…”

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confidence: 99%

“…This complication can be severe with purpura and bleeding [2]. According to several studies [2][3][4], brucellosis may present with severe hemorrhagic fever similar to CCHF, which requires isolation of the patients before definitive diagnosis. Therefore, brucellosis should be taken into consideration in endemic regions for the differential diagnosis of hematological conditions, such as pancytopenia, thrombocytopenia, hemolytic anemia, and disseminated intravascular coagulation [5][6].…”

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confidence: 99%

Acute Complicated Brucellosis Mimicking Crimean-Congo Hemorrhagic Fever (CCHF) and Vice Versa

Heydari

2019

JoMMID

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Crimean-Congo hemorrhagic fever (CCHF), endemic to Asia, Africa, and southern Europe, is a tick-borne disease caused by the CCHF virus (Orthonairovirus in Nairoviridae family). The main route of transmission is tick bite, and close contact with virus-infected blood/tissues of humans or animals may also transmit the infection. CCHF is considered a significant public health problem with case fatality rate (CFR) of 5.4-80% [1]. CCHF remains a seasonal disease and is rare in winter. In the case of similar epidemiologic and clinical presentation, brucellosis should be taken into consideration in endemic regions for the differential diagnosis of thrombocytopenia associated bleeding (with or without hemophagocytosis), because this picture is not rare in the latter illness [2]. After a few days (usually 2 to 14 days) incubation period, CCHF presents with nonspecific symptoms of fever, headache, body pain, and vomiting. During the hemorrhagic phase, petechia, ecchymosis, and bleeding from the various mucosal surface of the body, including respiratory tracts, genitourinary, and gastrointestinal tract can occur [3]. Severe CCHF can result in disseminated intravascular coagulation (DIC), shock, and death. Brucellosis, a prevalent zoonotic infection, is endemic to different regions of Mediterranean countries, the Balkans, the Persian Gulf, the Middle East, and Central and South America with a predominance of the agricultural and rural population [4]. This infection, caused by Brucella spp. a Gram-negative bacteria mimics different non-infectious and

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Hemophagocytosis and pulmonary involvement in brucellosis

Abstract: EJ, et al. Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients.

Cited by 8 publications

References 4 publications

Hemophagocytic syndrome associated with hepatitis A: case report and literature review

Hemophagocytic syndrome associated with hepatitis A: case report and literature review

Brucella-induced Thrombocytopenia and Bleeding

Acute Complicated Brucellosis Mimicking Crimean-Congo Hemorrhagic Fever (CCHF) and Vice Versa

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