Hemophagocytosis by leukemic blasts in 7 acute myeloid leukemia cases with t(16;21)(p11;q22)

Imashuku, Shinsaku; Hibi, Shigeyoshi; Shinoda, Masahiro; Lin, Ying‐Wei; Ikuta, Koichiro; Nakata, Yuji; Mori, Takeo; Iizuka, Susumu; Horibe, Keizo; Tsunematsu, Yukiko

doi:10.1002/(sici)1097-0142(20000415)88:8<1970::aid-cncr28>3.0.co;2-9

Cited by 45 publications

(45 citation statements)

References 19 publications

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“…All patients in their study had a relatively young age and poor prognosis [4]. In another study of 5 cases of AML showing hemophagocytosis by myeloid blasts, t(16;21)(p11;q22) was found.…”

Section: Discussionmentioning

confidence: 86%

“…Morphologically, hemophagocytic blasts with t(16;21) show single or multiple cytoplasmic vacuoles some of which are filled with homodense, creamy material. In addition, honeycomb like vacuoles with phagosomes have also been reported [4]. Two other cases of AML with complex cytogenetic abnormality showing hemophagocytosis have been described by Coulthard et al These patients had inv(8)(p11q13) [5].…”

Section: Discussionmentioning

confidence: 93%

“…Hemophagocytosis by leukemic blasts is an uncommon phenomenon and has been described in AML [2,4,5], ALL [6,7], chronic myelogenous leukemia (CML) in blast crisis [8] and myelodysplastic syndrome (MDS) [9].…”

Section: Discussionmentioning

confidence: 99%

“…In another study of 5 cases of AML showing hemophagocytosis by myeloid blasts, t(16;21)(p11;q22) was found. Four of these patients had acute megakaryoblastic leukemia [2].…”

Section: Discussionmentioning

confidence: 99%

“…In most cases, the histiocytes engulf hematopoietic cells [1]. However, hemophagocytosis by leukemic blasts is an uncommon phenomenon and has been reported in patients with acute myeloid leukemia (AML) especially acute megakaryoblastic leukemia [2]. Its occurrence in lymphoblastic leukemic blasts is rare [3].…”

Section: Introductionmentioning

confidence: 99%

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Hemophagocytosis by Leukemic Blasts in T Cell Acute Lymphoblastic Leukemia: An Unusual Finding

Harrison

Chandra

Kakkar

et al. 2015

Indian J Hematol Blood Transfus

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Hemophagocytosis shows engulfment of hematopoietic cells by histiocytes and is a property generally associated with cells of the histiocytic lineage. It can be familial or is seen in a wide spectrum of acquired disorders. Hemophagocytosis by leukemic blasts is an uncommon phenomenon and has been reported mainly in acute myeloid leukemia. Its association with acute lymphoblastic leukemia is rare. We present a case of hemophagocytosis by blasts in the bone marrow in a 11 year old boy with T cell-acute lymphoblastic leukemia.

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“…All patients in their study had a relatively young age and poor prognosis [4]. In another study of 5 cases of AML showing hemophagocytosis by myeloid blasts, t(16;21)(p11;q22) was found.…”

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

“…In another study of 5 cases of AML showing hemophagocytosis by myeloid blasts, t(16;21)(p11;q22) was found. Four of these patients had acute megakaryoblastic leukemia [2].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations