Hemophilic Pseudotumor of the Temporal Bone With Conductive Hearing Loss

Abstract

A 46-year-old man with factor VIII deficiency presented with a rare case of hemophilic pseudotumor in the temporal bone manifesting as severe conductive hearing loss and external ear bleeding. The pseudotumor expanded and destroyed the temporal bone and skin of the external ear over the course of 8 years. The pseudotumor was surgically excised, and the patient's symptoms improved. Histological examination of a specimen collected from inside the pseudotumor demonstrated blood products in various stages of evolution and showed that the outer membrane consisted of a collagen layer. Hemophilic pseudotumors are rare complications occurring in 1-2% of patients with mild or severe hemophilia. Pseudotumors are chronic, slowly expanding, encapsulated cystic masses, and most are located in the long bones and pelvis. The present case suggests that cranial pseudotumor should be considered in the differential diagnosis of cranial lesion in a patient with hemophilia.

Preparation of pigmented ink‐jet ink by a combination of surface treatments and synthetic dispersant

“…In this study, surface treatments have been carried out to improve the dispersion and ink-jet ink properties of carbon black pigment. Technically, the treatments can be carried out using two methods: oxidation of the surface and introduction of a polar group, such as a carboxylic acid group or benzene sulphonic acid group [14]. In this study, oxidising agents were used for surface treatments.…”

The diagnosis and treatment strategy of occipital skull mass in hemophilic patients: a rare case report and literature review

“…However, we can still identify a cHPT by some features. Previous cases showed 5/8 of patients with cHPT had a history of head trauma, and a hematoma often occurred after injury but were often not well treated [2,4,10,12,13]. One year later, there will be a progressively enlarging mass within the injury region [2,9].…”

Hemophilic Pseudotumor

“…They tend to be multiple and have a better prognosis. 17 Other sites include the mandible, orbit, paranasal sinuses, clavicle, A B orbit, 7 maxilla, 10 temporal bone, 18 and spinal canal. 19 Involvement of the cranial bone is extremely rare with <10 cases reported in the medical literature.…”

“…9 Surgery is generally curative and is cited as the most effective treatment for pseudotumor. 9,18,23 However (due to location, size, and other factors) not all pseudotumors are amenable to surgery. 2 Factor replacement therapy is a fundamental component of therapy regardless of any other interventions used.…”

“…2 However, the effect is temporary and it better serves as an adjunctive procedure, shrinking the lesion to make it more amenable to surgical resection. 2,18 Prophylactic factor VIII infusion regimens commonly prescribed for severe patients might provide protection against the formation of pseudotumors. Replacement factor infusions, particularly prophylaxis, are much less common among mild-to-moderate hemophilia patients.…”