2016
DOI: 10.1371/journal.pone.0156219
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Hemoporfin Photodynamic Therapy for Port-Wine Stain: A Randomized Controlled Trial

Abstract: Background and ObjectivesPhotodynamic therapy (PDT) has shown potentially beneficial results in treating port-wine stain, but its benefit–risk profile remains undefined. This study aimed to evaluate the efficacy and safety of PDT conducted with hemoporfin and a 532 nm continuous wave laser to treat port-wine stain clinically.Patients and MethodsThis randomized clinical trial was conducted in eight hospitals in China. Participants were adolescent and adult patients (age range: 14–65 years old) with port-wine st… Show more

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Cited by 70 publications
(82 citation statements)
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“…Vascular‐targeted PDT has been as an alternative and adjunctive treatment for PWS in China Recent phase IIa, IIb and III clinical trials of HMME‐mediated PDT have been completed, and showed a high level of clinical efficacy and minor adverse reactions in infant and pediatric patients . Yuan et al.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Vascular‐targeted PDT has been as an alternative and adjunctive treatment for PWS in China Recent phase IIa, IIb and III clinical trials of HMME‐mediated PDT have been completed, and showed a high level of clinical efficacy and minor adverse reactions in infant and pediatric patients . Yuan et al.…”
Section: Discussionmentioning
confidence: 99%
“…Vascular‐targeted photodynamic therapy (PDT) has been used to treat PWS since the 1990s . In 1990, Orenstein et al.…”
Section: Introductionmentioning
confidence: 99%
“…One randomized clinical trial compared PDT-Hemoporfin group with PDT-placebo group. It was reported that HMME-mediated PDT and 532 nm continuous wave laser was effective and safe for adolescent and adult patients with port-wine stains [54]. Tang et al [55] recruited 50 patients with PWS and assigned them randomly to the HMME-PDT group or the placebo group in session 1, both groups received HMME-PDT in the second session.…”
Section: Clinical Applicationsmentioning
confidence: 99%
“…Inclusion and exclusion criteria were similar as described previously . Briefly, the inclusion criteria were as follows: (1) clinical diagnosis of PWS; (2) age between 16 and 50 years old; (3) never received isotope or other systemic treatment for PWS; and (4) read and understood the treatment protocol and follow‐up requirements, and signed the informed consent documents.…”
Section: Methodsmentioning
confidence: 99%