“…Unopposed oestrogen was implicated in numerous cases of symptom recurrence ( n = 12) ( Skor et al , 1977 ; Stewart and Ireland, 1977 ; Kapadia et al , 1984 ; Ray et al , 1985 ; Manyonda et al , 1989 ; Taylor et al , 1999 , 2005 ; Badawy et al , 2004 ; Giarenis et al , 2009 ). Fewer studies reported recurrence in women who were using combined hormonal preparations (oestrogen and progestagen) ( n = 5) ( Goh and Hall, 1992 ; Joseph et al , 1994 ; Badawy et al , 2004 ; Chahine et al , 2007 ; Mattar et al , 2008 ). In terms of method of oestrogen administration, oral tablets ( n = 5) ( Skor et al , 1977 ; Stewart and Ireland, 1977 ; Kapadia et al , 1984 ; Ray et al , 1985 ; Goh and Hall, 1992 ), implants ( n = 6) ( Manyonda et al , 1989 ; Taylor et al , 1999 , 2005 ) and patches ( n = 3) ( Badawy et al , 2004 ; Taylor et al , 2005 ) were all reported.…”