Hemoptysis as the presenting manifestation of bronchiectasis-associated hospitalization in Korea

Seo, Hye-Won; Cha, Seung‐Ick; Park, Jongmin; Lim, Jae‐Kwang; Park, Ji‐Eun; Choi, Sun Ha; Lee, Yong Hoon; Yoo, Seung Soo; Lee, Shin-Yup; Lee, Jaehee; Kim, Chang‐Ho; Park, Jae Yong

doi:10.21037/jtd-22-1541

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…Our study demonstrated that bronchiectasis patients with hemoptysis had less severe bronchiectasis (the Reiff score for all but two patients was six or lower). This is in accordance with a study by Seo and colleagues who also showed that bronchiectasis with hemoptysis had a lower bronchiectasis severity and short-term mortality [31]. The explanation for those results and ours-with lower severity scores-may be that the hemoptysis phenotype is not associated with severe bronchiectasis but with specific etiology and radiological findings.…”

Section: Discussionsupporting

confidence: 93%

Phenotype and Clinicoradiological Differences in Multifocal and Focal Bronchiectasis

Jankovic,

Jandric,

Djurdjevic

et al. 2024

Medicina

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Introduction: Bronchiectasis is a chronic progressive respiratory disease characterized by permanent dilatation of the bronchi. It is a complex condition with numerous different etiologies, co-morbidities, and a heterogeneous presentation. As we know, there is a lack of studies that describe the differences and compare the characteristics between focal and multifocal bronchiectasis. The aim of this study is to identify differences in clinical characteristics presentation, severity or distribution in focal and multifocal bronchiectasis, and prognostic implications. Methods: 126 patients with computed tomography (CT)-verified bronchiectasis were enrolled. Baseline characteristics that included age, sex, smoking history, and respiratory symptoms were recorded, with special attention paid to hemoptysis appearance, body mass index, and comorbidities. The type of bronchiectasis determined by CT scan and the modified Reiff scores indicating radiological severity were recorded. Patients were divided in two groups (I is focal and II is multifocal). Results: There were no statistically significant differences in age, smoking status, comorbidity, and BMI between the two groups. Multifocality was associated with a significantly higher proportion of females (p = 0.014), the rate of hemoptysis (p = 0.023), and the number of hospitalizations, but not of exacerbations and prevalence of immunodeficiency (p = 0.049). Significantly, a high number of subjects with multifocality had bronchiectasis of moderate severity, and post-infective and asthma-associated phenotypes were the dominant in this group. Unexpectedly, the cystic and varicose radiological phenotype (which need more time to develop) were more dominant in the focal group. The cylindrical phenotype was equally observed in the multifocal and focal groups. Conclusions: Our study suggests that multifocality is not related to age, number of exacerbations, or radiological phenotype, but it seems to be associated with the clinical post-infective phenotype, immunodeficiency, frequent hospitalizations, and severity. Thus, the presence of multifocal bronchiectasis may act as a biomarker of severity and poor outcomes in these patients.

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Section: Discussionsupporting

confidence: 93%

Phenotype and Clinicoradiological Differences in Multifocal and Focal Bronchiectasis

Jankovic,

Jandric,

Djurdjevic

et al. 2024

Medicina

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“…Patients who had hemoptysis were less frequent in the lowest sex-specific PMA quartile group compared with other groups. Our previous study reported that bronchiectasis patients hospitalized with hemoptysis had a lower bronchiectasis severity and 30-day mortality than those with infective exacerbation [35]. In this study, the lowest sex-specific PMA quartile group was associated with higher severity and mortality, which may explain the low percentage of patients presenting with hemoptysis.…”

Section: Mortality In Bronchiectasis Exacerbationmentioning

confidence: 54%

Pectoralis Muscle Area as a Predictor of Mortality in Patients Hospitalized with Bronchiectasis Exacerbation

Seo,

Cha,

Park

et al. 2024

Respiration

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Introduction: Data on factors related to mortality in patients with bronchiectasis exacerbation are insufficient. Computed tomography (CT) can measure the pectoralis muscle area (PMA) and is a useful tool to diagnose sarcopenia. This study aimed to evaluate whether PMA can predict mortality in patients with bronchiectasis exacerbation. Methods: Patients hospitalized due to bronchiectasis exacerbation at a single center were retrospectively divided into survivors and non-survivors based on 1-year mortality. Thereafter, a comparison of the clinical and radiologic characteristics was conducted between the two groups. Results: A total of 66 (14%) patients died at 1 year. In the multivariate analysis, age, BMI <18.4 kg/m2, sex-specific PMA quartile, ≥3 exacerbations in the previous year, serum albumin <3.5 g/dL, cystic bronchiectasis, tuberculosis-destroyed lung, and diabetes mellitus were independent predictors for the 1-year mortality in patients hospitalized with bronchiectasis exacerbation. A lower PMA was associated with a lower overall survival rate in the survival analysis according to sex-specific quartiles of PMA. PMA had the highest area under the curve during assessment of prognostic performance in predicting the 1-year mortality. The lowest sex-specific PMA quartile group exhibited higher disease severity than the highest quartile group. Conclusions: CT-derived PMA was an independent predictor of 1-year mortality in patients hospitalized with bronchiectasis exacerbation. Patients with lower PMA exhibited higher disease severity. These findings suggest that PMA might be a useful marker for providing additional information regarding prognosis of patients with bronchiectasis exacerbation.

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“…Hemoptysis is frequently associated with bronchiectasis, occurring in 22–25% of afflicted patients [ 36 , 37 ]. A markedly higher proportion of bronchiectasis patients admitted due to hemoptysis have a history of pulmonary TB, with an odds ratio (OR) of 1.66 (95% confidence interval [CI], 1.03–2.69; p = 0.038) [ 41 ]. The increased prevalence of hemoptysis in post-TB bronchiectasis isn’t yet fully understood.…”

Section: Different Clinical Characteristics Of Ptldmentioning

confidence: 99%

“…The increased prevalence of hemoptysis in post-TB bronchiectasis isn’t yet fully understood. However, this group often exhibits marked reductions in lung function, as demonstrated by diminished forced expiratory volume in one second (FEV 1 ) and greater evidence of bronchial artery hypertrophy—a major hemoptysis contributor [ 41 – 44 ]. It’s conceivable that severe symptoms, such as consistent coughing and sputum production, could intensify pressures on nearby blood vessels.…”

Section: Different Clinical Characteristics Of Ptldmentioning

confidence: 99%

Long term management of people with post-tuberculosis lung disease

Seo,

Kim,

Kim

et al. 2024

Korean J Intern Med

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Post-tuberculosis lung disease (PTLD) is emerging as a significant area of global interest. As the number of patients surviving tuberculosis (TB) increases, the subsequent long-term repercussions have drawn increased attention due to their profound clinical and socioeconomic impacts. A primary obstacle to its comprehensive study has been its marked heterogeneity. The disease presents a spectrum of clinical manifestations which encompass tracheobronchial stenosis, bronchiectasis, granulomas with fibrosis, cavitation with associated aspergillosis, chronic pleural diseases, and small airway diseases—all persistent consequences of PTLD. The spectrum of symptoms a patient may experience varies based on the severity of the initial infection and the efficacy of the treatment received. As a result, the long-term management of PTLD necessitates a detailed and specific approach, addressing each manifestation individually—a tailored strategy. In the immediate aftermath (0–12 months after anti-TB chemotherapy), there should be an emphasis on monitoring for relapse, tracheobronchial stenosis, and smoking cessation. Subsequent management should focus on addressing hemoptysis, managing infection including aspergillosis, and TB-associated chronic obstructive pulmonary disease or restrictive lung function. There remains a vast expanse of knowledge to be discovered in PTLD. This review emphasizes the pressing need for comprehensive, consolidated guidelines for management of patients with PTLD.

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Hemoptysis as the presenting manifestation of bronchiectasis-associated hospitalization in Korea

Cited by 5 publications

References 34 publications

Phenotype and Clinicoradiological Differences in Multifocal and Focal Bronchiectasis

Phenotype and Clinicoradiological Differences in Multifocal and Focal Bronchiectasis

Pectoralis Muscle Area as a Predictor of Mortality in Patients Hospitalized with Bronchiectasis Exacerbation

Long term management of people with post-tuberculosis lung disease

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