Hemorheological Alteration in Patients Clinically Diagnosed with Chronic Liver Diseases

Abstract

Since liver function is changed by chronic liver diseases, chronic liver disease can lead to different hemorheological alterations during the course of the progression. This study aims to compare alterations in whole blood viscosity in patients with chronic liver disease, focusing on the gender effect. Chronic liver diseases were classified into three categories by patient’s history, serologic markers, and radiologic findings: nonalcoholic fatty liver disease (NAFLD) (n = 63), chronic viral hepatitis B and C (n = 50), and liver cirrhosis (LC) (n = 35). Whole blood viscosity was measured by automated scanning capillary tube viscometer, while liver stiffness was measured by transient elastography using FibroScan®. Both systolic and diastolic whole blood viscosities were significantly lower in patients with LC than NAFLD and chronic viral hepatitis (P < 0.001) in male patients, but not in female patients. In correlation analysis, there were inverse relationships between both systolic and diastolic whole blood viscosity and liver stiffness (systolic: r = −0.25, diastolic: r = −0.22). Whole blood viscosity was significantly lower in male patients with LC than NAFLD or chronic viral hepatitis. Our data suggest that whole blood viscosity test can become a useful tool for classifying chronic liver disease and determining the prognosis for different types of chronic liver diseases.

Fluids Alter Elasticity Measurements: Porous Wave Propagation Accounts for Shear Wave Dispersion in Elastography

“…The fluid viscosity in the poro-visco-elastic model is 3.1 mPas, which is below the commonly assumed whole blood viscosity of 3.5 mPas but above the viscosities given for microcirculation and interstitial fluid in the liver by [59]. In a recent study [75], observed an anti-correlation of blood viscosity with liver stiffness as measured by transient elastography. The authors suggested pathologic changes as the source of this anticorrelation.…”

“…Shear rate is a function of flow and vessel diameter, which vary widely throughout the liver [83]. We thus explicitly make the choice of reducing the model complexity by assuming an average Newtonian blood viscosity under systolic conditions as for example measured by [75]. The Biot parameters are interrelated, hence the sensitivity of the shear wave speed on one parameter depends on the choice of the others.…”

Hemorheological and Microcirculatory Factors in Liver Ischemia-Reperfusion Injury—An Update on Pathophysiology, Molecular Mechanisms and Protective Strategies

“…Furthermore, machine perfusion driven viability assessment during HMP/HOPE or NMP may support clinical decision in the acceptance or rejection of marginal liver allografts [ 4 , 6 , 184 ]. Besides refinement of the preservation techniques, the impact of hepatic dysfunction on macro- and micro-rheological parameters still need to be investigated, including metabolomics studies, to reveal better the local and systemic effects [ 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 ]. However, it would be interesting to overview it in a separate paper.…”

Intraoperative changes in whole-blood viscosity in patients undergoing robot-assisted laparoscopic prostatectomy in the steep Trendelenburg position with pneumoperitoneum: a prospective nonrandomized observational cohort study

“…WBV was measured during surgery three times via a central venous catheter: at the beginning of surgery (i.e., skin incision) in the supine position without pneumoperitoneum, after 30 min in the STP with pneumoperitoneum, and at the end of surgery (i.e., peritoneal closure) in the supine position without pneumoperitoneum (Table 1). Blood samples (3 mL) were collected into evacuated test tubes (BD Vacutainer, K2 EDTA; Becton, Dickinson and Company, Franklin Lakes, NJ, USA) without venous stasis, and measured using an automated scanning capillary tube viscometer (Hemovister; Ubiosis, Seongnam, Republic of Korea): WBV at a high shear rate (300 s − 1 ) was recorded as systolic blood viscosity (SBV) and that at a low shear rate (5 s − 1 ) was recorded as diastolic blood viscosity (DBV) [22]. The reference intervals for WBV were 3.5-4.1 cP at 5 s − 1 and 9.4-13.0 cP at 300 s − 1 in male patients, based on the manufacturer's instructions.…”