Hemorheological and metabolic consequences of renal ischemia-reperfusion and their modulation by N,N-dimethyl-tryptamine on a rat model

Pető, Károly; Németh, Norbert; Mester, Anita; Magyar, Zsuzsanna; Ghanem, Souleiman; Somogyi, Viktória; Tanczos, Bence; Deák, Ádám; Bidiga, László; Frecska, Ede; Nemes, Balázs

doi:10.3233/ch-170361

Cited by 13 publications

(6 citation statements)

References 28 publications

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“…DMT can also induce neuronal plasticity, a longer duration brain recuperative and repair process (Tsai et al 2009;Ruscher et al 2011;Kourrich et al 2012;Ly et al 2018;Olson 2018Olson , 2021. DMT has been shown to reduce infarct size and improve functional recovery following transient focal brain ischemia in rats (Nardai et al 2020), suggesting possible efficacy in post-ischemia and in stroke treatment or prevention and to prevent renal ischemia-reperfusion injury in a rat model as well (Peto et al, 2018;Nemes et al 2019). Sigma-1 receptors can also regulate cell survival and proliferation (Collina et al 2013;Frecska et al 2013).…”

Section: The In Vivo and In Vitro Effects Of Exogenous Dmtmentioning

confidence: 99%

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Barker

2022

Psychopharmacology

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As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on these factors as they relate to the psychedelic N,N-dimethyltryptamine (DMT). It will examine the positive and negative aspects of different formulations and routes of administration of DMT and the observed effects from such administrations in the form of ayahuasca teas; oral “pharmahuasca”; injections by intravenous (IV) and intramuscular (IM) routes; inhalation, insufflation; and other routes; and high-dose, low-dose, and “micro-dose” effects. The review will consider possible oral route of administration alternatives that would not require concomitant use of a monoamine oxidase inhibitor. The review will then address the current research findings for DMT from in vivo and in vitro studies as well as the possibility that these findings may be revealing the role of endogenous DMT in normal brain function.

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Section: The In Vivo and In Vitro Effects Of Exogenous Dmtmentioning

confidence: 99%

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Barker

2022

Psychopharmacology

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“…Hemorheological changes such as hypercoagulability, hyperviscosity and slow blood flow could accelerate renal impairment [21]. This study showed that hematocrit, erythrocyte aggregation index and erythrocyte count were significantly increased in DN rats.…”

Section: Discussionmentioning

confidence: 98%

“…The blood samples were obtained from heart and heparin anticoagulant tubes were used as the sampling tubes. The systematical changes of hemorheology of all rats were investigated by SA-5600 automatic hemorheology detector (Succeeder, China) [21].…”

Section: Methodsmentioning

confidence: 99%

Wenshen Jianpi recipe, a blended traditional Chinese medicine, ameliorates proteinuria and renal injury in a rat model of diabetic nephropathy

Cao¹,

Wei²,

Zhou³

et al. 2019

BMC Complement Altern Med

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Background Wenshen Jianpi recipe (WSJPR), a blended traditional Chinese medicine, is considered to have the possible beneficial effect on the progression of diabetic nephropathy (DN). This present study was designed to elucidate this protective activity in a rat model with streptozotocin (STZ)-induced DN and to explore the possible underlying mechanism. Methods Adult Sprague Dawley (SD) rats were induced to develop DN through intraperitoneal injection of STZ (60 mg/kg). Animals were orally administered saline, WSJPR at 7.5, 15, 30 g/kg, and valsartan (25 mg/kg) daily for 8 weeks. Blood and 24-h urine samples of each rat were collected for biochemical examination at 2-week intervals. Microcirculatory blood flow in the renal cortex and hemorheology index were also measured. At the end of 8 weeks, all rats were sacrificed to obtain the kidney tissues for histological examination and reverse transcription polymerase chain reaction (RT-PCR) was used to analyze the transcriptional levels of nephrin and podocin genes. Results WSJPR could improve serum total protein (TP) and albumin (ALB), reduce the excretion rates of urine-TP (U-TP), urine-ALB (U-ALB) and urine urea nitrogen (UUN) ( P < 0.05), although it did not significantly alter the hyperglycemia. In addition, treatment with WSJPR could strongly reduce blood flow, erythrocyte aggregation index, and ameliorate microcirculation. In histological measurement, WSJPR-treated rats showed a significant amelioration in glomerular hypertrophy and mesangial expansion. By RT-PCR, we found WSJPR up-regulated the nephrin and podocin expression at mRNA levels. Conclusion This study suggested that WSJPR could effectively relieve renal damage and improve renal function of DN rats by ameliorating metabolism disorder and increasing the gene expression of nephrin and podocin, which might be a useful approach for the treatment of DN.

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“…DMT also contributes to increased expression of delta opioid receptors, which play a key role in providing tissue resistance to loss of blood flow and oxidative stress (Zhang et al, 2006). DMT has been found to alleviate the effects of ischaemia-reperfusion injury (IRI) caused by hypoxia, oxidative stress and inflammation in preclinical models of kidney transplantation (Peto et al, 2018). The anti-inflammatory protective effect of DMT may represent a new, more beneficial method of reducing IRI-induced damage during organ transplantation.…”

Section: { Dmt-induced Immunomodulationmentioning

confidence: 99%

Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders

Schimmelpfennig,

Jankowiak-Siuda

2023

fpn

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This led researchers to consider the potential role of DMT as a neurotransmitter crucial for the survival of the organism under hypoxic conditions. The discovery of its immunomodulatory, neuroplastic, and body-protective properties against the effects of oxidative stress or damage sparked the scientific community's interest in DMT's therapeutic potential. In the first part of this paper, we show how DMT, as a psychoplastogen, i.e. a substance significantly stimulating mechanisms of structural and functional neuroplasticity in cortical areas, can be used in the treatment of Alzheimer's disease, brain damage, or frontotemporal dementia. Next, we show how neuroplastic changes occur through activation of sigma-1 and 5-HT 2A receptors. We also focus on its anti-inflammatory effects, protecting nerve and glial cells from oxidative stress, which shows therapeutic potential, especially in the treatment of depression, anxiety, or addiction. Finally, we outline the important effects of DMT on the biogenesis and proper functioning of mitochondria, whose dysfunction underlies many psychiatric, metabolic, neurodegenerative, and immunological disorders. Conclusions. The effects of DMT show therapeutic potential in the treatment of post-stroke, post-traumatic brain injury, transplantation or neurological and mitochondrial diseases, such as Alzheimer's and Parkinson's, frontotemporal dementia, amyotrophic lateral sclerosis, or multiple sclerosis. DMT shows therapeutic potential AbstrActObjectives. Outlining the therapeutic potential of dimethyltryptamine (DMT) from the perspective of its unique properties, mainly neuroplasticity and neuroprotection.Literature review. The first information on the therapeutic potential of DMT, commonly found in plants, humans and animals, appeared in the 1960s.

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Hemorheological and metabolic consequences of renal ischemia-reperfusion and their modulation by N,N-dimethyl-tryptamine on a rat model

Abstract: Metabolic and micro-rheological parameters impair during renal I/R. DMT could reduce but not completely prevent the changes in this rat model.

Cited by 13 publications

References 28 publications

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT

Wenshen Jianpi recipe, a blended traditional Chinese medicine, ameliorates proteinuria and renal injury in a rat model of diabetic nephropathy

Therapeutic potential of N,N-dimethyltryptamine in the treatment of psychiatric and neurodegenerative disorders

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